Detailed information of TA system TA081204

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3241458..3241983
• Replicon: chromosome
• Accession: NZ_CP023407
• Organism: Streptomyces fungicidicus strain TXX3120

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CNQ36_RS14530
• Protein ID: WP_121546319.1
• Coordinates: 3241717..3241983 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7H8J816
• Locus tag: CNQ36_RS14525
• Protein ID: WP_040908670.1
• Coordinates: 3241458..3241724 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ36_RS14495	3236922..3237683	+	762	WP_121546315.1	cobalt ECF transporter T component CbiQ	-
CNQ36_RS14500	3237671..3238441	+	771	WP_121546316.1	energy-coupling factor ABC transporter ATP-binding protein	-
CNQ36_RS14505	3238453..3238923	+	471	WP_004930328.1	MarR family transcriptional regulator	-
CNQ36_RS14510	3238981..3240201	+	1221	WP_121546317.1	serine hydrolase	-
CNQ36_RS14515	3240202..3240477	-	276	WP_121546318.1	DUF1876 domain-containing protein	-
CNQ36_RS14520	3240558..3241403	-	846	WP_004930321.1	DMT family transporter	-
CNQ36_RS14525	3241458..3241724	+	267	WP_040908670.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CNQ36_RS14530	3241717..3241983	+	267	WP_121546319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CNQ36_RS14535	3242090..3244297	-	2208	WP_121546320.1	MMPL family transporter	-
CNQ36_RS14540	3244398..3244997	-	600	WP_004930314.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-57)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10199.72 Da
• Isoelectric Point: 10.2960

>T81204 WP_121546319.1 NZ_CP023407:3241717-3241983 [Streptomyces fungicidicus]
VSSGYRTVFRPEAQAELRKIPRDMALRILVKLTELETDPLGFRTTALVSRPDRRRLRVGDYRVIYTIDNGELTVWVVHVG
HRSTVYDT

Nucleotide

• Length: 267 bp

>T81204 NZ_CP023407:3241717-3241983 [Streptomyces fungicidicus]
GTGAGTAGCGGCTACCGCACCGTCTTCCGGCCGGAGGCTCAGGCGGAGCTTCGCAAGATTCCCCGGGACATGGCCCTGAG
GATCCTGGTCAAACTGACGGAACTGGAAACGGACCCGCTCGGCTTCCGCACCACGGCGCTCGTCTCCCGGCCCGACCGGC
GCCGGCTCCGTGTCGGCGACTACCGCGTCATCTACACGATCGACAACGGCGAGTTGACGGTCTGGGTCGTTCATGTCGGA
CACCGCTCCACGGTATACGACACCTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10218.61 Da
• Isoelectric Point: 4.5329

>AT81204 WP_040908670.1 NZ_CP023407:3241458-3241724 [Streptomyces fungicidicus]
MTEMPIESIRDVRAHLAEVVERADRDDTPTVITRRGKQVAAVVSMEVLRKYQEWEEREINRIIDERMANPAAGIPIEDVM
RETLERGE

Nucleotide

• Length: 267 bp

>AT81204 NZ_CP023407:3241458-3241724 [Streptomyces fungicidicus]
ATGACCGAGATGCCCATAGAGTCCATTCGTGACGTGCGCGCCCACCTGGCCGAGGTGGTCGAACGGGCGGACCGGGACGA
CACGCCCACGGTCATCACCCGGCGAGGCAAGCAGGTGGCCGCAGTCGTGTCGATGGAGGTCCTTCGCAAGTACCAGGAAT
GGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCGAACCCGGCAGCCGGTATCCCGATCGAGGACGTCATG
CGGGAGACGCTGGAGCGCGGTGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7H8J816