Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 859972..860449 Replicon chromosome
Accession NZ_CP023390
Organism Staphylococcus aureus subsp. aureus str. Newman strain NYU_Newman

Toxin (Protein)


Gene name TsaT Uniprot ID A0A0H3K6W0
Locus tag CNH35_RS04455 Protein ID WP_000052077.1
Coordinates 859972..860160 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CNH35_RS04460 Protein ID WP_001059690.1
Coordinates 860189..860449 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNH35_RS04425 856013..856483 + 471 WP_000824472.1 hypothetical protein -
CNH35_RS04430 856824..857510 + 687 WP_001548082.1 thermonuclease family protein -
CNH35_RS04435 857867..858067 + 201 WP_001059082.1 cold-shock protein -
CNH35_RS04440 858563..858781 - 219 WP_000005886.1 hypothetical protein -
CNH35_RS04445 858843..859127 - 285 WP_001004395.1 hypothetical protein -
CNH35_RS04450 859215..859784 - 570 WP_001106654.1 hypothetical protein -
CNH35_RS04455 859972..860160 - 189 WP_000052077.1 hypothetical protein Toxin
CNH35_RS04460 860189..860449 - 261 WP_001059690.1 hypothetical protein Antitoxin
CNH35_RS04465 860790..860993 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CNH35_RS04470 860990..861226 - 237 WP_000368687.1 hypothetical protein -
CNH35_RS04475 861451..862032 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CNH35_RS04480 862105..862722 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
CNH35_RS04485 862877..863371 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
CNH35_RS04490 863770..864192 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CNH35_RS04495 864340..865056 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7186.87 Da        Isoelectric Point: 9.9971

>T81166 WP_000052077.1 NZ_CP023390:c860160-859972 [Staphylococcus aureus subsp. aureus str. Newman]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTIILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T81166 NZ_CP023390:c860160-859972 [Staphylococcus aureus subsp. aureus str. Newman]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTATCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT81166 WP_001059690.1 NZ_CP023390:c860449-860189 [Staphylococcus aureus subsp. aureus str. Newman]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT81166 NZ_CP023390:c860449-860189 [Staphylococcus aureus subsp. aureus str. Newman]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3K6W0

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References