81160

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1785..2332 Replicon plasmid p74
Accession NZ_CP023389
Organism Escherichia coli strain 1105

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag CNQ47_RS25910 Protein ID WP_000969996.1
Coordinates 2051..2332 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag CNQ47_RS25905 Protein ID WP_000079941.1
Coordinates 1785..2054 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ47_RS25890 13..870 + 858 WP_054627963.1 incFII family plasmid replication initiator RepA -
CNQ47_RS25905 1785..2054 + 270 WP_000079941.1 hypothetical protein Antitoxin
CNQ47_RS25910 2051..2332 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNQ47_RS25915 2378..3226 + 849 WP_001554372.1 3'-5' exonuclease -
CNQ47_RS25920 3343..3825 + 483 WP_001311056.1 hypothetical protein -
CNQ47_RS25930 4127..4474 + 348 WP_000142450.1 hypothetical protein -
CNQ47_RS25935 4492..4725 - 234 WP_096058003.1 hypothetical protein -
CNQ47_RS25940 4787..5212 + 426 WP_000422741.1 IS66 family insertion sequence hypothetical protein -
CNQ47_RS25945 5209..5559 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -
CNQ47_RS25950 5590..7203 + 1614 Protein_10 IS66-like element ISEc23 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..74094 74094


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T81160 WP_000969996.1 NZ_CP023389:2051-2332 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T81160 NZ_CP023389:2051-2332 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT81160 WP_000079941.1 NZ_CP023389:1785-2054 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT81160 NZ_CP023389:1785-2054 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCTGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAACGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References