Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3029239..3030040 Replicon chromosome
Accession NZ_CP023388
Organism Escherichia coli strain 1105

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag CNQ47_RS15680 Protein ID WP_000854739.1
Coordinates 3029239..3029619 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag CNQ47_RS15685 Protein ID WP_001285482.1
Coordinates 3029666..3030040 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ47_RS15645 3024830..3025384 - 555 WP_001001913.1 molecular chaperone YcdY -
CNQ47_RS15650 3025408..3026145 - 738 WP_000283656.1 zinc-binding phosphatase -
CNQ47_RS15655 3026200..3027138 - 939 WP_000351277.1 glyoxylate/hydroxypyruvate reductase GhrA -
CNQ47_RS15665 3027625..3028452 - 828 WP_001304477.1 DUF4942 domain-containing protein -
CNQ47_RS15670 3028537..3028734 - 198 WP_000772027.1 DUF957 domain-containing protein -
CNQ47_RS15675 3028754..3029242 - 489 WP_001054232.1 hypothetical protein -
CNQ47_RS15680 3029239..3029619 - 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
CNQ47_RS15685 3029666..3030040 - 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CNQ47_RS15690 3030090..3030734 - 645 WP_000086763.1 hypothetical protein -
CNQ47_RS15695 3030753..3030974 - 222 WP_000692315.1 DUF987 domain-containing protein -
CNQ47_RS15700 3031037..3031513 - 477 WP_001186170.1 RadC family protein -
CNQ47_RS15705 3031529..3032002 - 474 WP_000855076.1 antirestriction protein -
CNQ47_RS15710 3032265..3033086 - 822 WP_001234710.1 DUF945 domain-containing protein -
CNQ47_RS26845 3033167..3033378 + 212 Protein_2878 hypothetical protein -
CNQ47_RS15725 3033497..3033952 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T81148 WP_000854739.1 NZ_CP023388:c3029619-3029239 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T81148 NZ_CP023388:c3029619-3029239 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGTCCCGTCGCAGTTAATCAACAGCATCGATATTCTCCGGGCCCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATGACATTACCCTGGGCAGGCATCCGGAGGAGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT81148 WP_001285482.1 NZ_CP023388:c3030040-3029666 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT81148 NZ_CP023388:c3030040-3029666 [Escherichia coli]
GTGTCAGACACGCTCCATGAAACAAATTATCCCGACGACAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCAGT
TCAGCGACGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References