Detailed information of TA system TA081136

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 1415852..1416510
• Replicon: chromosome
• Accession: NZ_CP023388
• Organism: Escherichia coli strain 1105

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: CNQ47_RS07285
• Protein ID: WP_001683207.1
• Coordinates: 1415852..1416172 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: CNQ47_RS07290
• Protein ID: WP_001683206.1
• Coordinates: 1416193..1416510 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ47_RS07265	1411275..1412723	-	1449	Protein_1318	NADP-dependent succinate-semialdehyde dehydrogenase	-
CNQ47_RS07270	1412746..1414014	-	1269	WP_000271996.1	L-2-hydroxyglutarate oxidase	-
CNQ47_RS07275	1414034..1415011	-	978	WP_000993119.1	carbon starvation induced protein CsiD	-
CNQ47_RS07285	1415852..1416172	-	321	WP_001683207.1	TA system toxin CbtA family protein	Toxin
CNQ47_RS07290	1416193..1416510	-	318	WP_001683206.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CNQ47_RS07295	1416529..1416750	-	222	WP_001683205.1	DUF987 domain-containing protein	-
CNQ47_RS07300	1416759..1417238	-	480	WP_001683204.1	DNA repair protein RadC	-
CNQ47_RS07305	1417250..1417708	-	459	WP_001683203.1	antirestriction protein	-
CNQ47_RS26485	1417705..1417941	-	237	WP_071591061.1	DUF905 family protein	-
CNQ47_RS07315	1418139..1419206	-	1068	WP_001683202.1	hypothetical protein	-
CNQ47_RS07320	1419497..1420207	-	711	WP_001683200.1	DeoR family transcriptional regulator	-
CNQ47_RS07325	1420416..1421240	-	825	WP_001683199.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1394001..1417708	23707

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-104)

Antitoxin

• Antitoxin CbeA (5-104)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12145.20 Da
• Isoelectric Point: 9.0174

>T81136 WP_001683207.1 NZ_CP023388:c1416172-1415852 [Escherichia coli]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQKQSPFITAVDILKARRAMREMRT

Nucleotide

• Length: 321 bp

>T81136 NZ_CP023388:c1416172-1415852 [Escherichia coli]
ATGAAAACTCTACCTGCAACAACTTTGTGGGCGGCTAAACCATGTCCGTCACCAGTGATCGTATGGCAAATGCTTCTTTC
ACGCCTGCTGGATCAGCACTATGGCCTGACACTGAACGACACGCCATTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGCCGATGCCGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATCGATCGTAAGGGGTTT
AGCTGGCAAAAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAACTTA
A

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 12025.59 Da
• Isoelectric Point: 6.6251

>AT81136 WP_001683206.1 NZ_CP023388:c1416510-1416193 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYIYITVYPTQR

Nucleotide

• Length: 318 bp

>AT81136 NZ_CP023388:c1416510-1416193 [Escherichia coli]
ATGAGCAACATCACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGTAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGCCATGCCCACTGCGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACATATACATCACCGTTTATCCCACTCAACGTTAA