Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1415852..1416510 Replicon chromosome
Accession NZ_CP023388
Organism Escherichia coli strain 1105

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag CNQ47_RS07285 Protein ID WP_001683207.1
Coordinates 1415852..1416172 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag CNQ47_RS07290 Protein ID WP_001683206.1
Coordinates 1416193..1416510 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ47_RS07265 1411275..1412723 - 1449 Protein_1318 NADP-dependent succinate-semialdehyde dehydrogenase -
CNQ47_RS07270 1412746..1414014 - 1269 WP_000271996.1 L-2-hydroxyglutarate oxidase -
CNQ47_RS07275 1414034..1415011 - 978 WP_000993119.1 carbon starvation induced protein CsiD -
CNQ47_RS07285 1415852..1416172 - 321 WP_001683207.1 TA system toxin CbtA family protein Toxin
CNQ47_RS07290 1416193..1416510 - 318 WP_001683206.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CNQ47_RS07295 1416529..1416750 - 222 WP_001683205.1 DUF987 domain-containing protein -
CNQ47_RS07300 1416759..1417238 - 480 WP_001683204.1 DNA repair protein RadC -
CNQ47_RS07305 1417250..1417708 - 459 WP_001683203.1 antirestriction protein -
CNQ47_RS26485 1417705..1417941 - 237 WP_071591061.1 DUF905 family protein -
CNQ47_RS07315 1418139..1419206 - 1068 WP_001683202.1 hypothetical protein -
CNQ47_RS07320 1419497..1420207 - 711 WP_001683200.1 DeoR family transcriptional regulator -
CNQ47_RS07325 1420416..1421240 - 825 WP_001683199.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1394001..1417708 23707


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-104)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12145.20 Da        Isoelectric Point: 9.0174

>T81136 WP_001683207.1 NZ_CP023388:c1416172-1415852 [Escherichia coli]
MKTLPATTLWAAKPCPSPVIVWQMLLSRLLDQHYGLTLNDTPFSDETVIKEHIDAGISLADAVNFLVEKYELVRIDRKGF
SWQKQSPFITAVDILKARRAMREMRT

Download         Length: 321 bp

>T81136 NZ_CP023388:c1416172-1415852 [Escherichia coli]
ATGAAAACTCTACCTGCAACAACTTTGTGGGCGGCTAAACCATGTCCGTCACCAGTGATCGTATGGCAAATGCTTCTTTC
ACGCCTGCTGGATCAGCACTATGGCCTGACACTGAACGACACGCCATTCAGTGATGAAACTGTGATTAAGGAACATATCG
ATGCCGGTATCTCTTTAGCCGATGCCGTTAATTTTCTGGTGGAAAAATACGAACTGGTTCGCATCGATCGTAAGGGGTTT
AGCTGGCAAAAACAGTCGCCTTTTATTACTGCTGTAGACATTCTAAAAGCCAGACGGGCTATGAGGGAAATGAGAACTTA
A

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12025.59 Da        Isoelectric Point: 6.6251

>AT81136 WP_001683206.1 NZ_CP023388:c1416510-1416193 [Escherichia coli]
MSNITWGLQRDITPRLGARLVQEGNRLHYLADRASITGKFSDVECRKLDETFPHFISQMESMLTTDELNPRHAHCVTLYH
NGFTCEADTLGSCGYIYITVYPTQR

Download         Length: 318 bp

>AT81136 NZ_CP023388:c1416510-1416193 [Escherichia coli]
ATGAGCAACATCACATGGGGGCTGCAGCGGGATATCACGCCACGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGTAAATTCAGTGACGTCGAATGCCGTAAGCTGGATGAAACATTCCCGC
ACTTTATCAGCCAGATGGAGTCGATGCTGACCACCGATGAACTGAATCCCCGCCATGCCCACTGCGTCACCCTGTACCAC
AATGGTTTCACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACATATACATCACCGTTTATCCCACTCAACGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References