Detailed information of TA system TA081134

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 977006..977841
• Replicon: chromosome
• Accession: NZ_CP023388
• Organism: Escherichia coli strain 1105

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CNQ47_RS05075
• Protein ID: WP_001683029.1
• Coordinates: 977006..977383 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: E3PJ72
• Locus tag: CNQ47_RS05080
• Protein ID: WP_001278232.1
• Coordinates: 977473..977841 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ47_RS05050	973078..974061	-	984	WP_001298261.1	KpsF/GutQ family sugar-phosphate isomerase	-
CNQ47_RS05055	974872..975042	-	171	Protein_920	IS110 family transposase	-
CNQ47_RS05060	975385..976227	-	843	WP_001519083.1	DUF4942 domain-containing protein	-
CNQ47_RS05065	976312..976509	-	198	WP_001519084.1	DUF957 domain-containing protein	-
CNQ47_RS05070	976521..977009	-	489	WP_001519085.1	hypothetical protein	-
CNQ47_RS05075	977006..977383	-	378	WP_001683029.1	TA system toxin CbtA family protein	Toxin
CNQ47_RS05080	977473..977841	-	369	WP_001278232.1	type IV toxin-antitoxin system toxin CbtA	Antitoxin
CNQ47_RS05085	978004..978225	-	222	WP_000692315.1	DUF987 domain-containing protein	-
CNQ47_RS05090	978294..978770	-	477	WP_001186727.1	RadC family protein	-
CNQ47_RS05095	978786..979265	-	480	WP_019842849.1	antirestriction protein	-
CNQ47_RS05105	979604..980422	-	819	WP_021524998.1	DUF945 domain-containing protein	-
CNQ47_RS05115	980512..980745	-	234	WP_001278282.1	DUF905 family protein	-
CNQ47_RS05120	980751..981428	-	678	WP_001519094.1	hypothetical protein	-
CNQ47_RS05125	981576..982256	-	681	WP_001282920.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14347.36 Da
• Isoelectric Point: 8.7451

>T81134 WP_001683029.1 NZ_CP023388:c977383-977006 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFSDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPRF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T81134 NZ_CP023388:c977383-977006 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCCCCGGTTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13491.37 Da
• Isoelectric Point: 6.6290

>AT81134 WP_001278232.1 NZ_CP023388:c977841-977473 [Escherichia coli]
VSDALSGTMLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSGGYVYLAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT81134 NZ_CP023388:c977841-977473 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: E3PJ72