Detailed information of TA system TA081129

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 86894..87692
• Replicon: chromosome
• Accession: NZ_CP023388
• Organism: Escherichia coli strain 1105

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CNQ47_RS00450
• Protein ID: WP_001609485.1
• Coordinates: 86894..87271 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CNQ47_RS00455
• Protein ID: WP_001609483.1
• Coordinates: 87318..87692 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ47_RS00415	82258..83076	+	819	WP_000779409.1	lipoprotein NlpA	-
CNQ47_RS00420	83080..84003	-	924	WP_000535950.1	carboxylate/amino acid/amine transporter	-
CNQ47_RS00425	84170..84667	-	498	WP_000509811.1	hypothetical protein	-
CNQ47_RS00435	85260..86104	-	845	Protein_82	DUF4942 domain-containing protein	-
CNQ47_RS00440	86200..86397	-	198	WP_001609487.1	DUF957 domain-containing protein	-
CNQ47_RS00445	86409..86897	-	489	WP_001609486.1	hypothetical protein	-
CNQ47_RS00450	86894..87271	-	378	WP_001609485.1	TA system toxin CbtA family protein	Toxin
CNQ47_RS00455	87318..87692	-	375	WP_001609483.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CNQ47_RS00460	87742..88386	-	645	WP_001609482.1	hypothetical protein	-
CNQ47_RS00465	88405..88626	-	222	WP_001609480.1	DUF987 domain-containing protein	-
CNQ47_RS00470	88695..89171	-	477	WP_001186188.1	RadC family protein	-
CNQ47_RS00475	89187..89666	-	480	WP_021563547.1	antirestriction protein	-
CNQ47_RS00480	89748..90566	-	819	WP_096057945.1	DUF945 domain-containing protein	-
CNQ47_RS00485	90665..90976	-	312	WP_001608658.1	hypothetical protein	-
CNQ47_RS00495	91315..91593	-	279	WP_001545361.1	hypothetical protein	-
CNQ47_RS00500	91854..92534	-	681	WP_096057946.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14276.23 Da
• Isoelectric Point: 7.2141

>T81129 WP_001609485.1 NZ_CP023388:c87271-86894 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKYPEAKQ

Nucleotide

• Length: 378 bp

>T81129 NZ_CP023388:c87271-86894 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGTTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACTCCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCTGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGTAAGTATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 13675.54 Da
• Isoelectric Point: 6.4603

>AT81129 WP_001609483.1 NZ_CP023388:c87692-87318 [Escherichia coli]
VSDTLPGTTLPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYHLDQAFPLLMKQLKLMLTSG
ELNPCHQHTVTLYAKGLTCEADTFGSCGYVYLAVYPTLAPATTS

Nucleotide

• Length: 375 bp

>AT81129 NZ_CP023388:c87692-87318 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGCGCCCGTCTGGTGCAGGAAGGGAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGGGACGCAGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGCGGT
GAACTGAATCCCTGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCTTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACTGGCACCCGCAACCACTTCATAA