Detailed information of TA system TA081125

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4256417..4257231
• Replicon: chromosome
• Accession: NZ_CP023386
• Organism: Escherichia coli strain 1190

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: CNQ48_RS21675
• Protein ID: WP_001054376.1
• Coordinates: 4256417..4256674 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: CNQ48_RS21680
• Protein ID: WP_001309181.1
• Coordinates: 4256686..4257231 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ48_RS21640	4251705..4252811	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
CNQ48_RS21645	4252876..4253856	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
CNQ48_RS21655	4254439..4255679	-	1241	Protein_3994	helicase YjhR	-
CNQ48_RS21665	4255795..4256040	+	246	Protein_3995	GNAT family N-acetyltransferase	-
CNQ48_RS21675	4256417..4256674	+	258	WP_001054376.1	hypothetical protein	Toxin
CNQ48_RS21680	4256686..4257231	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
CNQ48_RS21685	4257287..4258033	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
CNQ48_RS21690	4258202..4258420	+	219	Protein_3999	hypothetical protein	-
CNQ48_RS25960	4258458..4258574	+	117	Protein_4000	VOC family protein	-
CNQ48_RS21700	4258819..4259940	+	1122	WP_000010829.1	M42 family metallopeptidase	-
CNQ48_RS21705	4259937..4260215	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
CNQ48_RS21710	4260227..4261540	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4248911..4265455	16544

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T81125 WP_001054376.1 NZ_CP023386:4256417-4256674 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T81125 NZ_CP023386:4256417-4256674 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT81125 WP_001309181.1 NZ_CP023386:4256686-4257231 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT81125 NZ_CP023386:4256686-4257231 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8