81107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 951785..952439 Replicon chromosome
Accession NZ_CP023386
Organism Escherichia coli strain 1190

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag CNQ48_RS04815 Protein ID WP_000244777.1
Coordinates 952032..952439 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7B2N3K9
Locus tag CNQ48_RS04810 Protein ID WP_001604807.1
Coordinates 951785..952051 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ48_RS04785 947068..947811 + 744 WP_001366570.1 SDR family oxidoreductase -
CNQ48_RS04790 947873..949306 - 1434 WP_001604813.1 6-phospho-beta-glucosidase BglA -
CNQ48_RS04795 949351..949662 + 312 WP_001604811.1 N(4)-acetylcytidine aminohydrolase -
CNQ48_RS04800 949826..950485 + 660 WP_000250269.1 hemolysin III family protein -
CNQ48_RS04805 950562..951542 - 981 WP_001604809.1 tRNA-modifying protein YgfZ -
CNQ48_RS04810 951785..952051 + 267 WP_001604807.1 FAD assembly factor SdhE Antitoxin
CNQ48_RS04815 952032..952439 + 408 WP_000244777.1 toxin CptA Toxin
CNQ48_RS04820 952479..953000 - 522 WP_001055874.1 flavodoxin FldB -
CNQ48_RS04825 953112..954008 + 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
CNQ48_RS04830 954033..954743 + 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CNQ48_RS04835 954749..956482 + 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T81107 WP_000244777.1 NZ_CP023386:952032-952439 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T81107 NZ_CP023386:952032-952439 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGTCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10595.21 Da        Isoelectric Point: 5.6375

>AT81107 WP_001604807.1 NZ_CP023386:951785-952051 [Escherichia coli]
MYINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT81107 NZ_CP023386:951785-952051 [Escherichia coli]
ATGTACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCGGACC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7B2N3K9

References