Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 58886..59445 Replicon plasmid p147
Accession NZ_CP023384
Organism Escherichia coli strain 1223

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag CNQ49_RS24730 Protein ID WP_032219250.1
Coordinates 58886..59161 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag CNQ49_RS24735 Protein ID WP_072262158.1
Coordinates 59161..59445 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ49_RS24695 54031..55911 - 1881 WP_021511745.1 colicin 1A -
CNQ49_RS24700 56190..57536 - 1347 WP_032219247.1 hypothetical protein -
CNQ49_RS24710 57890..58084 + 195 Protein_50 proQ/FINO family protein -
CNQ49_RS24715 58084..58275 + 192 WP_072262157.1 hypothetical protein -
CNQ49_RS24720 58272..58550 + 279 WP_157732781.1 hypothetical protein -
CNQ49_RS24725 58499..58780 - 282 WP_032219248.1 hypothetical protein -
CNQ49_RS24730 58886..59161 - 276 WP_032219250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNQ49_RS24735 59161..59445 - 285 WP_072262158.1 ribbon-helix-helix domain-containing protein Antitoxin
CNQ49_RS24740 60180..60501 + 322 Protein_56 abortive infection protein -
CNQ49_RS24745 60701..61329 - 629 Protein_57 DUF4238 domain-containing protein -
CNQ49_RS24750 61390..62478 + 1089 WP_032219254.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD iroB / iroC / iroD / iroE / iroN / iucA 1..147369 147369


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10781.51 Da        Isoelectric Point: 9.9324

>T81090 WP_032219250.1 NZ_CP023384:c59161-58886 [Escherichia coli]
MELKWTSKALSDLARLYDFLMLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T81090 NZ_CP023384:c59161-58886 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGATGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10500.91 Da        Isoelectric Point: 5.6558

>AT81090 WP_072262158.1 NZ_CP023384:c59445-59161 [Escherichia coli]
IQMKNNSAQTTKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQIIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp

>AT81090 NZ_CP023384:c59445-59161 [Escherichia coli]
ATACAAATGAAAAACAATAGTGCACAAACAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGATTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACGGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References