Detailed information of TA system TA081089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/-
• Location: 45032..45408
• Replicon: plasmid p147
• Accession: NZ_CP023384
• Organism: Escherichia coli strain 1223

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A075MDK3
• Locus tag: CNQ49_RS24615
• Protein ID: WP_000969988.1
• Coordinates: 45032..45214 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: CNQ49_RS24620
• Protein ID: WP_001324224.1
• Coordinates: 45211..45408 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ49_RS24595	43031..44065	-	1035	WP_001190234.1	3-deoxy-7-phosphoheptulonate synthase	-
CNQ49_RS24610	44625..44933	-	309	WP_000377483.1	hypothetical protein	-
CNQ49_RS24615	45032..45214	-	183	WP_000969988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CNQ49_RS24620	45211..45408	-	198	WP_001324224.1	toxin-antitoxin system protein	Antitoxin
CNQ49_RS24630	46090..47364	+	1275	WP_000489608.1	HlyD family secretion protein	-
CNQ49_RS24635	47339..49453	+	2115	WP_001183604.1	peptidase domain-containing ABC transporter	-
CNQ49_RS24640	49623..49934	-	312	WP_001259758.1	colicin V	-
CNQ49_RS26280	49912..50148	-	237	WP_001323890.1	colicin V immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	sitABCD	iroB / iroC / iroD / iroE / iroN / iucA	1..147369	147369

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6931.07 Da
• Isoelectric Point: 4.5349

>T81089 WP_000969988.1 NZ_CP023384:c45214-45032 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGCSASLLFSLSFISVQVHDNIITV

Nucleotide

• Length: 183 bp

>T81089 NZ_CP023384:c45214-45032 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTGTTCAGCCAGCCTCCTGTTCTCCCTTTCTTTTATCAGTGTACAGGTGC
ATGACAACATAATCACGGTATGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7658.53 Da
• Isoelectric Point: 7.2046

>AT81089 WP_001324224.1 NZ_CP023384:c45408-45211 [Escherichia coli]
MDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRDEMSRKVAGK

Nucleotide

• Length: 198 bp

>AT81089 NZ_CP023384:c45408-45211 [Escherichia coli]
ATGGACCGTAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGA
CCAGGTTGAGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCAT
GGCGGGATGAAATGAGCAGGAAAGTCGCCGGTAAATGA

Structures

Toxin

• AlphaFold DB: A0A075MDK3