Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3917714..3918549 Replicon chromosome
Accession NZ_CP023383
Organism Escherichia coli strain 1223

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag CNQ49_RS20200 Protein ID WP_023180999.1
Coordinates 3918172..3918549 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A167E9A4
Locus tag CNQ49_RS20195 Protein ID WP_023181000.1
Coordinates 3917714..3918082 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ49_RS20150 3913900..3914436 + 537 WP_001000101.1 DUF4234 domain-containing protein -
CNQ49_RS20155 3914512..3914733 + 222 WP_024144968.1 DUF905 family protein -
CNQ49_RS20165 3914824..3915642 + 819 WP_023181002.1 DUF945 domain-containing protein -
CNQ49_RS20170 3915734..3916219 + 486 WP_023181001.1 antirestriction protein -
CNQ49_RS20180 3916235..3916711 + 477 WP_001424026.1 RadC family protein -
CNQ49_RS20185 3916780..3917001 + 222 WP_000692353.1 DUF987 domain-containing protein -
CNQ49_RS20190 3917020..3917664 + 645 WP_024144967.1 hypothetical protein -
CNQ49_RS20195 3917714..3918082 + 369 WP_023181000.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CNQ49_RS20200 3918172..3918549 + 378 WP_023180999.1 TA system toxin CbtA family protein Toxin
CNQ49_RS20205 3918546..3919034 + 489 WP_000761678.1 hypothetical protein -
CNQ49_RS20210 3919046..3919243 + 198 WP_000839240.1 DUF957 domain-containing protein -
CNQ49_RS20215 3919328..3920194 + 867 WP_021547704.1 DUF4942 domain-containing protein -
CNQ49_RS20220 3920266..3920529 + 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
CNQ49_RS20225 3920526..3920852 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
CNQ49_RS20230 3921316..3922578 + 1263 WP_032161224.1 integrase arm-type DNA-binding domain-containing protein -
CNQ49_RS20235 3922807..3923504 - 698 Protein_3696 IS1 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3883623..3971781 88158


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14103.15 Da        Isoelectric Point: 8.2905

>T81085 WP_023180999.1 NZ_CP023383:3918172-3918549 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTRSQLINSIDILRARRATGLMARENYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T81085 NZ_CP023383:3918172-3918549 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACCGACCAGCCGGGGTTC
AGCACCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
AAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13747.48 Da        Isoelectric Point: 5.9618

>AT81085 WP_023181000.1 NZ_CP023383:3917714-3918082 [Escherichia coli]
VSDSLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT81085 NZ_CP023383:3917714-3918082 [Escherichia coli]
GTGTCAGACTCACTCCATGAAACAAATTATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTTGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGCTACGTTTATATGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A167E9A4

References