Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2791742..2792577 Replicon chromosome
Accession NZ_CP023383
Organism Escherichia coli strain 1223

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag CNQ49_RS14510 Protein ID WP_000854761.1
Coordinates 2792200..2792577 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag CNQ49_RS14505 Protein ID WP_001295723.1
Coordinates 2791742..2792110 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ49_RS14460 2787085..2787345 - 261 Protein_2622 transposase -
CNQ49_RS14465 2787409..2788071 - 663 Protein_2623 ISL3 family transposase -
CNQ49_RS14470 2788362..2788766 - 405 WP_001221631.1 zinc-ribbon domain-containing protein -
CNQ49_RS14475 2788951..2789919 + 969 Protein_2625 IS110 family transposase -
CNQ49_RS14480 2789929..2790321 - 393 WP_001352248.1 hypothetical protein -
CNQ49_RS14485 2790487..2791056 - 570 WP_000221554.1 inovirus Gp2 family protein -
CNQ49_RS14500 2791358..2791579 + 222 WP_000692345.1 DUF987 domain-containing protein -
CNQ49_RS14505 2791742..2792110 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CNQ49_RS14510 2792200..2792577 + 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
CNQ49_RS14515 2792574..2792776 + 203 Protein_2631 hypothetical protein -
CNQ49_RS26155 2792789..2792902 + 114 WP_001161660.1 DUF957 domain-containing protein -
CNQ49_RS14520 2793337..2794041 - 705 Protein_2633 IS66-like element ISEc22 family transposase -
CNQ49_RS14530 2794644..2795015 + 372 WP_001295631.1 IS110 family transposase -
CNQ49_RS14540 2795469..2795651 + 183 WP_024167529.1 ethanolamine utilization protein -
CNQ49_RS14545 2795752..2796081 - 330 WP_000450409.1 DUF496 family protein -
CNQ49_RS14550 2796253..2797311 - 1059 WP_001200892.1 FUSC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2793337..2794023 686


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T81081 WP_000854761.1 NZ_CP023383:2792200-2792577 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T81081 NZ_CP023383:2792200-2792577 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT81081 WP_001295723.1 NZ_CP023383:2791742-2792110 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT81081 NZ_CP023383:2791742-2792110 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References