Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2360370..2360896 Replicon chromosome
Accession NZ_CP023383
Organism Escherichia coli strain 1223

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag CNQ49_RS12135 Protein ID WP_000323025.1
Coordinates 2360370..2360657 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag CNQ49_RS12140 Protein ID WP_000534858.1
Coordinates 2360657..2360896 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ49_RS12095 2355394..2355609 - 216 WP_000839590.1 phage lysis protein EssD -
CNQ49_RS26570 2355829..2355999 + 171 WP_211180497.1 putative zinc-binding protein YnfU -
CNQ49_RS12100 2356363..2356578 - 216 WP_000066484.1 cold shock-like protein CspB -
CNQ49_RS12105 2356879..2357091 + 213 WP_000087756.1 cold shock-like protein CspF -
CNQ49_RS26120 2357146..2357235 + 90 WP_120795389.1 hypothetical protein -
CNQ49_RS12110 2357513..2358265 - 753 WP_001047135.1 antitermination protein -
CNQ49_RS12115 2358279..2359328 - 1050 WP_001265199.1 DUF968 domain-containing protein -
CNQ49_RS12120 2359330..2359608 - 279 WP_012304870.1 hypothetical protein -
CNQ49_RS12125 2359675..2359926 - 252 WP_000980994.1 hypothetical protein -
CNQ49_RS12130 2360143..2360298 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
CNQ49_RS12135 2360370..2360657 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
CNQ49_RS12140 2360657..2360896 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
CNQ49_RS12145 2360921..2361226 + 306 WP_001326990.1 hypothetical protein -
CNQ49_RS12150 2361429..2361761 + 333 WP_001301033.1 protein FlxA -
CNQ49_RS12155 2362198..2363511 - 1314 WP_000589005.1 ISNCY family transposase -
CNQ49_RS26375 2364280..2364567 - 288 Protein_2199 hypothetical protein -
CNQ49_RS12180 2364789..2364887 + 99 Protein_2200 IS66 family insertion sequence element accessory protein TnpB -
CNQ49_RS12185 2364935..2365168 + 234 WP_001341330.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2345182..2383436 38254


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T81072 WP_000323025.1 NZ_CP023383:c2360657-2360370 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T81072 NZ_CP023383:c2360657-2360370 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT81072 WP_000534858.1 NZ_CP023383:c2360896-2360657 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT81072 NZ_CP023383:c2360896-2360657 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References