Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 1835764..1836599 | Replicon | chromosome |
Accession | NZ_CP023377 | ||
Organism | Escherichia coli strain 127 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A2T3T4L0 |
Locus tag | CNQ50_RS09425 | Protein ID | WP_001556084.1 |
Coordinates | 1835764..1836141 (-) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A403D757 |
Locus tag | CNQ50_RS09430 | Protein ID | WP_016230789.1 |
Coordinates | 1836231..1836599 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CNQ50_RS09390 | 1831284..1831757 | + | 474 | WP_001105407.1 | DNA gyrase inhibitor SbmC | - |
CNQ50_RS09395 | 1831955..1833013 | + | 1059 | WP_001200895.1 | FUSC family protein | - |
CNQ50_RS09400 | 1833185..1833514 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
CNQ50_RS09405 | 1833615..1833797 | - | 183 | WP_024174802.1 | ethanolamine utilization protein | - |
CNQ50_RS28090 | 1834251..1834640 | - | 390 | WP_102804527.1 | transposase | - |
CNQ50_RS27785 | 1835438..1835551 | - | 114 | WP_032140621.1 | DUF957 domain-containing protein | - |
CNQ50_RS09420 | 1835564..1835767 | - | 204 | WP_000761705.1 | hypothetical protein | - |
CNQ50_RS09425 | 1835764..1836141 | - | 378 | WP_001556084.1 | TA system toxin CbtA family protein | Toxin |
CNQ50_RS09430 | 1836231..1836599 | - | 369 | WP_016230789.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
CNQ50_RS09435 | 1836762..1836983 | - | 222 | WP_000692345.1 | DUF987 domain-containing protein | - |
CNQ50_RS09440 | 1837046..1837522 | - | 477 | WP_001186775.1 | RadC family protein | - |
CNQ50_RS09445 | 1837538..1838011 | - | 474 | WP_001765426.1 | antirestriction protein | - |
CNQ50_RS09455 | 1838353..1839171 | - | 819 | WP_020239663.1 | DUF945 domain-containing protein | - |
CNQ50_RS09465 | 1839326..1839484 | - | 159 | WP_001323397.1 | DUF905 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14232.27 Da Isoelectric Point: 7.8276
>T81034 WP_001556084.1 NZ_CP023377:c1836141-1835764 [Escherichia coli]
MKTLPDTHVRELSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
MKTLPDTHVRELSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR
Download Length: 378 bp
>T81034 NZ_CP023377:c1836141-1835764 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGTTATCGCGCTGCCCATCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGTTATCGCGCTGCCCATCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13614.45 Da Isoelectric Point: 7.0264
>AT81034 WP_016230789.1 NZ_CP023377:c1836599-1836231 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT81034 NZ_CP023377:c1836599-1836231 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2T3T4L0 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A403D757 |