Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1835764..1836599 Replicon chromosome
Accession NZ_CP023377
Organism Escherichia coli strain 127

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2T3T4L0
Locus tag CNQ50_RS09425 Protein ID WP_001556084.1
Coordinates 1835764..1836141 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A403D757
Locus tag CNQ50_RS09430 Protein ID WP_016230789.1
Coordinates 1836231..1836599 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ50_RS09390 1831284..1831757 + 474 WP_001105407.1 DNA gyrase inhibitor SbmC -
CNQ50_RS09395 1831955..1833013 + 1059 WP_001200895.1 FUSC family protein -
CNQ50_RS09400 1833185..1833514 + 330 WP_000450409.1 DUF496 family protein -
CNQ50_RS09405 1833615..1833797 - 183 WP_024174802.1 ethanolamine utilization protein -
CNQ50_RS28090 1834251..1834640 - 390 WP_102804527.1 transposase -
CNQ50_RS27785 1835438..1835551 - 114 WP_032140621.1 DUF957 domain-containing protein -
CNQ50_RS09420 1835564..1835767 - 204 WP_000761705.1 hypothetical protein -
CNQ50_RS09425 1835764..1836141 - 378 WP_001556084.1 TA system toxin CbtA family protein Toxin
CNQ50_RS09430 1836231..1836599 - 369 WP_016230789.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
CNQ50_RS09435 1836762..1836983 - 222 WP_000692345.1 DUF987 domain-containing protein -
CNQ50_RS09440 1837046..1837522 - 477 WP_001186775.1 RadC family protein -
CNQ50_RS09445 1837538..1838011 - 474 WP_001765426.1 antirestriction protein -
CNQ50_RS09455 1838353..1839171 - 819 WP_020239663.1 DUF945 domain-containing protein -
CNQ50_RS09465 1839326..1839484 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14232.27 Da        Isoelectric Point: 7.8276

>T81034 WP_001556084.1 NZ_CP023377:c1836141-1835764 [Escherichia coli]
MKTLPDTHVRELSRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T81034 NZ_CP023377:c1836141-1835764 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGTTATCGCGCTGCCCATCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13614.45 Da        Isoelectric Point: 7.0264

>AT81034 WP_016230789.1 NZ_CP023377:c1836599-1836231 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT81034 NZ_CP023377:c1836599-1836231 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2T3T4L0


Antitoxin

Source ID Structure
AlphaFold DB A0A403D757

References