Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2375846..2376484 Replicon chromosome
Accession NZ_CP023371
Organism Escherichia coli strain 1283

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag CNQ51_RS12205 Protein ID WP_001447010.1
Coordinates 2376308..2376484 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CNQ51_RS12200 Protein ID WP_001270286.1
Coordinates 2375846..2376262 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ51_RS12180 2370998..2371939 - 942 WP_001251304.1 ABC transporter permease -
CNQ51_RS12185 2371940..2372953 - 1014 WP_000220395.1 ABC transporter ATP-binding protein -
CNQ51_RS12190 2372971..2374116 - 1146 WP_000047428.1 ABC transporter substrate-binding protein -
CNQ51_RS12195 2374361..2375767 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
CNQ51_RS12200 2375846..2376262 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
CNQ51_RS12205 2376308..2376484 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
CNQ51_RS12210 2376706..2376936 + 231 WP_000494244.1 YncJ family protein -
CNQ51_RS12215 2377028..2378989 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
CNQ51_RS12220 2379062..2379598 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
CNQ51_RS12225 2379651..2380865 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T81010 WP_001447010.1 NZ_CP023371:c2376484-2376308 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T81010 NZ_CP023371:c2376484-2376308 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT81010 WP_001270286.1 NZ_CP023371:c2376262-2375846 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT81010 NZ_CP023371:c2376262-2375846 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References