Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 22477..23030 Replicon plasmid p111
Accession NZ_CP023367
Organism Escherichia coli strain 1428

Toxin (Protein)


Gene name relE Uniprot ID S1PMX5
Locus tag CNQ52_RS25495 Protein ID WP_000421257.1
Coordinates 22755..23030 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2P9EG58
Locus tag CNQ52_RS25490 Protein ID WP_001595223.1
Coordinates 22477..22755 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ52_RS25470 18771..20651 + 1881 WP_001595229.1 colicin 1B -
CNQ52_RS25475 20669..21016 - 348 WP_001595228.1 hypothetical protein -
CNQ52_RS25480 21135..21482 + 348 WP_001595227.1 hypothetical protein -
CNQ52_RS25485 21604..22390 + 787 Protein_24 IS21 family transposase -
CNQ52_RS25490 22477..22755 + 279 WP_001595223.1 ribbon-helix-helix domain-containing protein Antitoxin
CNQ52_RS25495 22755..23030 + 276 WP_000421257.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNQ52_RS25500 23136..23417 + 282 WP_001595222.1 hypothetical protein -
CNQ52_RS27915 23855..24091 + 237 WP_137498364.1 colicin V immunity protein -
CNQ52_RS25515 24544..25494 + 951 WP_001595221.1 omptin family outer membrane protease -
CNQ52_RS25520 25679..27163 + 1485 WP_096040775.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroE / iroD / iroC / iroB 1..111523 111523


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10749.45 Da        Isoelectric Point: 9.9324

>T80986 WP_000421257.1 NZ_CP023367:22755-23030 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

>T80986 NZ_CP023367:22755-23030 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10243.62 Da        Isoelectric Point: 5.6558

>AT80986 WP_001595223.1 NZ_CP023367:22477-22755 [Escherichia coli]
MKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQIIDHQAVQAWAD
SLSTDNPLPVPR

Download         Length: 279 bp

>AT80986 NZ_CP023367:22477-22755 [Escherichia coli]
ATGAAAAACAATACCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGACCAGAT
GGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGGAGCGTA
ATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGATTATCGACCATCAGGCTGTACAGGCCTGGGCGGAC
AGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PMX5

Antitoxin

Source ID Structure
AlphaFold DB A0A2P9EG58

References