Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 6291..7048 Replicon plasmid p111
Accession NZ_CP023367
Organism Escherichia coli strain 1428

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag CNQ52_RS25400 Protein ID WP_001595243.1
Coordinates 6563..7048 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag CNQ52_RS25395 Protein ID WP_001352814.1
Coordinates 6291..6575 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ52_RS25370 2477..2746 + 270 WP_000079928.1 hypothetical protein -
CNQ52_RS25375 2743..3024 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin -
CNQ52_RS25380 3070..3918 + 849 WP_001595246.1 3'-5' exonuclease -
CNQ52_RS25385 4035..4517 + 483 WP_001311056.1 hypothetical protein -
CNQ52_RS25390 4677..5699 + 1023 WP_001595244.1 IS110 family transposase -
CNQ52_RS25395 6291..6575 + 285 WP_001352814.1 DUF1778 domain-containing protein Antitoxin
CNQ52_RS25400 6563..7048 + 486 WP_001595243.1 GNAT family N-acetyltransferase Toxin
CNQ52_RS25410 7369..7641 + 273 Protein_10 transposase family protein -
CNQ52_RS25415 7728..8303 + 576 WP_001595242.1 tyrosine-type recombinase/integrase -
CNQ52_RS25420 8763..9356 + 594 WP_001595241.1 type 1 fimbrial protein -
CNQ52_RS25425 9430..10134 + 705 WP_001595240.1 molecular chaperone -
CNQ52_RS25430 10220..10552 + 333 WP_001595237.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroE / iroD / iroC / iroB 1..111523 111523
- flank IS/Tn - - 4677..5699 1022


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-151)

Antitoxin

Vibrio phage ICP1, Orf50

(8-93)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17605.39 Da        Isoelectric Point: 9.2645

>T80985 WP_001595243.1 NZ_CP023367:6563-7048 [Escherichia coli]
MGCVTAPEPLSSFHQVAEFVSGEIVLDDWLKQKGLKNQALGATRTFVVCRKGTQQVVGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDASFRGKGLGADLLHDAVCRCYRVAENIGVRAIMVHALTESAKQFYIHHGFTPSKTQVQTLFLKLP
Q

Download         Length: 486 bp

>T80985 NZ_CP023367:6563-7048 [Escherichia coli]
ATGGGATGTGTAACAGCACCAGAACCTTTATCCTCATTTCATCAGGTCGCTGAATTTGTCAGCGGTGAAATTGTTCTTGA
TGACTGGTTAAAGCAGAAGGGGCTAAAAAATCAGGCTCTCGGAGCCACCCGGACTTTTGTTGTATGCAGGAAAGGTACGC
AACAAGTAGTCGGTTTTTACTCACTGGCTACTGGCAGTGTCAACCATACAGAAGCTACAGGCAATCTTCGGCGCAATATG
CCTGACCCCATTCCTGTCATTATACTTGCACGTCTGGCTGTTGATGCGTCATTCCGTGGTAAAGGGCTTGGTGCAGATTT
GCTGCATGATGCGGTTTGTCGTTGTTACAGAGTGGCCGAAAATATCGGTGTGCGTGCAATTATGGTTCATGCACTTACGG
AAAGCGCAAAACAGTTTTATATTCATCATGGCTTTACGCCATCAAAAACCCAGGTGCAAACATTGTTTCTTAAACTCCCT
CAGTAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10915.58 Da        Isoelectric Point: 4.6926

>AT80985 WP_001352814.1 NZ_CP023367:6291-6575 [Escherichia coli]
MIYGGFMKSGVQLNLRARESQRILIDTAAEILHKSRTDFILEMACKAAEDVILDRRVFNFNDRQYEEFIEMLDAPVADEP
AIEKLLARKPQWDV

Download         Length: 285 bp

>AT80985 NZ_CP023367:6291-6575 [Escherichia coli]
ATGATATACGGAGGCTTTATGAAATCAGGTGTTCAGCTCAACCTCAGAGCAAGAGAGTCACAGCGGATACTCATTGATAC
CGCTGCAGAAATTCTTCATAAGTCACGTACAGACTTCATTCTGGAAATGGCCTGTAAAGCTGCTGAAGATGTTATTCTCG
ATCGGCGAGTGTTTAATTTTAATGACAGGCAATATGAAGAGTTCATCGAAATGCTTGATGCCCCGGTTGCAGATGAACCT
GCCATCGAAAAATTGCTGGCAAGGAAACCCCAATGGGATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References