Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4594554..4595597 Replicon chromosome
Accession NZ_CP023366
Organism Escherichia coli strain 1428

Toxin (Protein)


Gene name panT Uniprot ID A0A7Z8DXL5
Locus tag CNQ52_RS23390 Protein ID WP_021563277.1
Coordinates 4594554..4595102 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag CNQ52_RS23395 Protein ID WP_000287252.1
Coordinates 4595124..4595597 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ52_RS23340 4589707..4589907 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
CNQ52_RS23345 4589998..4590672 + 675 WP_000848748.1 LexA family transcriptional repressor -
CNQ52_RS23350 4590907..4591113 + 207 WP_000549623.1 hypothetical protein -
CNQ52_RS23355 4591085..4591519 - 435 WP_000016389.1 hypothetical protein -
CNQ52_RS27890 4591663..4591973 + 311 Protein_4303 hypothetical protein -
CNQ52_RS23370 4591988..4592350 + 363 WP_000135682.1 hypothetical protein -
CNQ52_RS23375 4592416..4593240 + 825 WP_023307624.1 DUF2303 family protein -
CNQ52_RS23380 4593459..4594211 + 753 WP_029396186.1 hypothetical protein -
CNQ52_RS23385 4594248..4594520 + 273 WP_022630955.1 pyocin activator PrtN family protein -
CNQ52_RS23390 4594554..4595102 - 549 WP_021563277.1 hypothetical protein Toxin
CNQ52_RS23395 4595124..4595597 - 474 WP_000287252.1 SocA family protein Antitoxin
CNQ52_RS23400 4595884..4596006 - 123 WP_001300034.1 hypothetical protein -
CNQ52_RS23405 4596506..4597372 - 867 WP_157732838.1 DUF2713 family protein -
CNQ52_RS23410 4597690..4598205 + 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
CNQ52_RS23415 4598247..4598456 - 210 WP_001296638.1 CsbD family protein -
CNQ52_RS23420 4598572..4599897 - 1326 WP_001361471.1 MATE family efflux transporter DinF -
CNQ52_RS23425 4599970..4600578 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4553967..4600578 46611


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 19952.40 Da        Isoelectric Point: 4.5662

>T80983 WP_021563277.1 NZ_CP023366:c4595102-4594554 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQVFKSAFEPSNHESDDDSSSENKAILEAEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKPPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T80983 NZ_CP023366:c4595102-4594554 [Escherichia coli]
ATGTCTCACAATTCAGATATCTATAAACTTATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAACAGGTTTTTAAATCTGCATTTGAGCCGTCTAATCATGAGAGCGACGATGATTCTTCTTCAG
AAAATAAAGCTATTCTGGAGGCAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTTCGGACAAAAATGGCCTCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGCCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT80983 WP_000287252.1 NZ_CP023366:c4595597-4595124 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT80983 NZ_CP023366:c4595597-4595124 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCAA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z8DXL5

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References