Detailed information of TA system TA080980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4251576..4252390
• Replicon: chromosome
• Accession: NZ_CP023366
• Organism: Escherichia coli strain 1428

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: CNQ52_RS21420
• Protein ID: WP_001054376.1
• Coordinates: 4251576..4251833 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: U9Z4B8
• Locus tag: CNQ52_RS21425
• Protein ID: WP_001309181.1
• Coordinates: 4251845..4252390 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ52_RS21385	4246865..4247971	+	1107	WP_074471845.1	N-acetylneuraminate epimerase	-
CNQ52_RS21390	4248036..4249016	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
CNQ52_RS21400	4249599..4250838	-	1240	Protein_3955	helicase YjhR	-
CNQ52_RS21410	4250954..4251199	+	246	Protein_3956	GNAT family N-acetyltransferase	-
CNQ52_RS21420	4251576..4251833	+	258	WP_001054376.1	hypothetical protein	Toxin
CNQ52_RS21425	4251845..4252390	+	546	WP_001309181.1	N-acetyltransferase	Antitoxin
CNQ52_RS21430	4252446..4253192	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
CNQ52_RS21435	4253361..4253579	+	219	Protein_3960	hypothetical protein	-
CNQ52_RS28035	4253617..4253733	+	117	Protein_3961	VOC family protein	-
CNQ52_RS21445	4253978..4255099	+	1122	WP_000010829.1	M42 family metallopeptidase	-
CNQ52_RS21450	4255096..4255374	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
CNQ52_RS21455	4255386..4256699	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB	4244071..4260614	16543

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T80980 WP_001054376.1 NZ_CP023366:4251576-4251833 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T80980 NZ_CP023366:4251576-4251833 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19956.90 Da
• Isoelectric Point: 6.3277

>AT80980 WP_001309181.1 NZ_CP023366:4251845-4252390 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT80980 NZ_CP023366:4251845-4252390 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82

Antitoxin

• AlphaFold DB: U9Z4B8