80924

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 118727..119274 Replicon plasmid 134q
Accession NZ_CP023363
Organism Escherichia coli strain 144

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag CNQ53_RS00780 Protein ID WP_000969996.1
Coordinates 118993..119274 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag CNQ53_RS00775 Protein ID WP_000079941.1
Coordinates 118727..118996 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ53_RS27400 114027..114377 + 351 WP_000454193.1 DUF3330 domain-containing protein -
CNQ53_RS00755 114553..115113 + 561 WP_001161490.1 recombinase family protein -
CNQ53_RS00760 115117..118083 + 2967 WP_001138014.1 Tn3-like element TnAs1 family transposase -
CNQ53_RS00775 118727..118996 + 270 WP_000079941.1 hypothetical protein Antitoxin
CNQ53_RS00780 118993..119274 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNQ53_RS00785 119320..120168 + 849 WP_001057989.1 3'-5' exonuclease -
CNQ53_RS00790 120354..122234 + 1881 WP_001283335.1 colicin -
CNQ53_RS00795 122256..122591 - 336 WP_001080729.1 colicin 1A immunity protein -
CNQ53_RS00805 122720..122977 + 258 WP_000142431.1 hypothetical protein -
CNQ53_RS00810 122997..123587 - 591 WP_001518980.1 hypothetical protein -
CNQ53_RS00815 123584..123844 - 261 WP_000343091.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid sitABCD / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B / dfrA5 iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA 1..134388 134388


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T80924 WP_000969996.1 NZ_CP023363:118993-119274 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T80924 NZ_CP023363:118993-119274 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT80924 WP_000079941.1 NZ_CP023363:118727-118996 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT80924 NZ_CP023363:118727-118996 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References