Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3534397..3535015 Replicon chromosome
Accession NZ_CP023359
Organism Escherichia coli strain 1943

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag CNQ54_RS18180 Protein ID WP_001291435.1
Coordinates 3534797..3535015 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag CNQ54_RS18175 Protein ID WP_000344800.1
Coordinates 3534397..3534771 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ54_RS18165 3529486..3530679 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CNQ54_RS18170 3530702..3533851 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
CNQ54_RS18175 3534397..3534771 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
CNQ54_RS18180 3534797..3535015 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
CNQ54_RS18185 3535187..3535738 + 552 WP_000102568.1 maltose O-acetyltransferase -
CNQ54_RS18190 3535854..3536324 + 471 WP_000136192.1 YlaC family protein -
CNQ54_RS18195 3536488..3538038 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
CNQ54_RS18200 3538080..3538433 - 354 WP_000878141.1 DUF1428 family protein -
CNQ54_RS18210 3538812..3539123 + 312 WP_000409911.1 MGMT family protein -
CNQ54_RS18215 3539154..3539726 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T80912 WP_001291435.1 NZ_CP023359:3534797-3535015 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T80912 NZ_CP023359:3534797-3535015 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT80912 WP_000344800.1 NZ_CP023359:3534397-3534771 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT80912 NZ_CP023359:3534397-3534771 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References