Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 96755..97410 Replicon plasmid p100
Accession NZ_CP023358
Organism Escherichia coli strain 317

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag CNQ55_RS26195 Protein ID WP_096037721.1
Coordinates 96755..97183 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag CNQ55_RS26200 Protein ID WP_042021192.1
Coordinates 97180..97410 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ55_RS26175 92187..92960 + 774 WP_042021199.1 outer membrane protein assembly factor BamE -
CNQ55_RS26180 93599..94363 + 765 WP_157740265.1 YadA-like family protein -
CNQ55_RS26185 94446..94928 + 483 WP_042021198.1 hypothetical protein -
CNQ55_RS26760 95360..95449 - 90 Protein_101 IS3 family transposase -
CNQ55_RS26195 96755..97183 - 429 WP_096037721.1 type II toxin-antitoxin system VapC family toxin Toxin
CNQ55_RS26200 97180..97410 - 231 WP_042021192.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CNQ55_RS26210 98008..98226 + 219 WP_000813639.1 type II toxin-antitoxin system antitoxin CcdA -
CNQ55_RS26215 98228..98533 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB -
CNQ55_RS26220 98534..99340 + 807 WP_077781165.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - pic 1..100008 100008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-133)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15712.26 Da        Isoelectric Point: 8.2873

>T80897 WP_096037721.1 NZ_CP023358:c97183-96755 [Escherichia coli]
MKQPRTKTYMLDTCICSFIMREQPDAVLKRLEQAVLRNHRIVVSAITYAEMRFGATGPKASPRHIELVDAFCARLDAILP
WDRAAVDATTNIKVALRTAGTPIGPNDTAIAGHAITAGAILVTNNVREFERVPDLVLEDWVK

Download         Length: 429 bp

>T80897 NZ_CP023358:c97183-96755 [Escherichia coli]
ATGAAACAGCCCCGCACGAAAACCTATATGCTCGATACCTGCATCTGCTCGTTCATCATGCGTGAGCAGCCGGACGCCGT
GCTGAAACGCCTGGAGCAGGCAGTGCTGCGTAATCACCGGATTGTGGTGTCGGCCATCACCTACGCCGAGATGCGCTTTG
GCGCCACCGGTCCAAAGGCCTCGCCGCGCCACATTGAGCTGGTAGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCG
TGGGACCGGGCTGCGGTGGACGCCACCACCAACATTAAGGTGGCGCTGCGTACCGCCGGCACGCCCATCGGACCAAACGA
CACTGCCATCGCCGGGCATGCCATTACCGCCGGGGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGAGGGTGCCTG
ACCTGGTGCTGGAAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8802.98 Da        Isoelectric Point: 4.3895

>AT80897 WP_042021192.1 NZ_CP023358:c97410-97180 [Escherichia coli]
MRTVSIFRNGNNRAIRLPRDLDFEGVSELEIIREGDSIILRPVRPTWSSFLELEKADPDFMAEREVIVSDEGRVEL

Download         Length: 231 bp

>AT80897 NZ_CP023358:c97410-97180 [Escherichia coli]
ATGCGAACAGTATCTATTTTCAGAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAAGGGGTAAG
CGAACTCGAAATCATCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGAGTTCATTCCTAGAGTTAG
AAAAGGCCGATCCGGACTTTATGGCAGAGCGTGAGGTGATTGTTAGCGACGAAGGACGCGTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References