Detailed information of TA system TA080895

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4688951..4689771
• Replicon: chromosome
• Accession: NZ_CP023357
• Organism: Escherichia coli strain 317

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: Q83W73
• Locus tag: CNQ55_RS23875
• Protein ID: WP_000854700.1
• Coordinates: 4689394..4689771 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CNQ55_RS23870
• Protein ID: WP_021552835.1
• Coordinates: 4688951..4689304 (+)
• Length: 118 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CNQ55_RS23830	4684383..4685288	+	906	WP_000203550.1	chemotaxis protein	-
CNQ55_RS23835	4685285..4686355	+	1071	WP_096037647.1	patatin-like phospholipase family protein	-
CNQ55_RS23850	4686694..4687512	+	819	WP_096037648.1	DUF945 domain-containing protein	-
CNQ55_RS23855	4687604..4688089	+	486	WP_096037649.1	antirestriction protein	-
CNQ55_RS23860	4688105..4688581	+	477	WP_001186199.1	RadC family protein	-
CNQ55_RS23865	4688650..4688871	+	222	WP_000692353.1	DUF987 domain-containing protein	-
CNQ55_RS23870	4688951..4689304	+	354	WP_021552835.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CNQ55_RS23875	4689394..4689771	+	378	WP_000854700.1	TA system toxin CbtA family protein	Toxin
CNQ55_RS23880	4689768..4690256	+	489	WP_096037650.1	hypothetical protein	-
CNQ55_RS23885	4690268..4690465	+	198	WP_096037651.1	DUF957 domain-containing protein	-
CNQ55_RS23890	4690550..4691392	+	843	WP_096037652.1	DUF4942 domain-containing protein	-
CNQ55_RS23900	4692141..4693679	+	1539	WP_001187191.1	lysine decarboxylation/transport transcriptional activator CadC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (13-112)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14276.28 Da
• Isoelectric Point: 7.8046

>T80895 WP_000854700.1 NZ_CP023357:4689394-4689771 [Escherichia coli]
MKTLPDTHVREASRCLSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SPCTRSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Nucleotide

• Length: 378 bp

>T80895 NZ_CP023357:4689394-4689771 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCTGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AAGCAGGGATTTCACTGTGTGACGCGGTGAATTTTCTCGTTGAAAAATACGCCCTGGTGCGTACTGACCAGCCGGGATTC
AGCCCCTGTACCCGCTCTCAGTTAATCAACAGTATCGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCGGGGTAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 118 a.a.
• Molecular weight: 12909.62 Da
• Isoelectric Point: 6.4643

>AT80895 WP_021552835.1 NZ_CP023357:4688951-4689304 [Escherichia coli]
VSDTLPDDNNDSPWWGLPCTVTPCFGARLVQEGNSLHYLADRAGIRGRFSDADANHLNQAFPLLMKQLKLMLTSGELNPR
HQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Nucleotide

• Length: 354 bp

>AT80895 NZ_CP023357:4688951-4689304 [Escherichia coli]
GTGTCAGACACACTCCCCGACGACAACAACGACAGCCCCTGGTGGGGACTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACAGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGTTCAGCGACGCGGATG
CGAACCATCTGAACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAACTCATGCTCACCAGCGGTGAACTGAATCCCCGC
CATCAGCATACCGTCACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A454A1I2