Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2147750..2148566 | Replicon | chromosome |
| Accession | NZ_CP023357 | ||
| Organism | Escherichia coli strain 317 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1P968 |
| Locus tag | CNQ55_RS10580 | Protein ID | WP_000854814.1 |
| Coordinates | 2147750..2148124 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | CNQ55_RS10585 | Protein ID | WP_198319677.1 |
| Coordinates | 2148213..2148566 (-) | Length | 118 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CNQ55_RS10545 | 2143146..2144312 | + | 1167 | WP_001297905.1 | serine-type D-Ala-D-Ala carboxypeptidase DacD | - |
| CNQ55_RS10550 | 2144431..2144904 | + | 474 | WP_001105376.1 | DNA gyrase inhibitor SbmC | - |
| CNQ55_RS10555 | 2145102..2146160 | + | 1059 | WP_001200890.1 | FUSC family protein | - |
| CNQ55_RS10560 | 2146332..2146661 | + | 330 | WP_000450409.1 | DUF496 family protein | - |
| CNQ55_RS10565 | 2146762..2146944 | - | 183 | WP_001016348.1 | hypothetical protein | - |
| CNQ55_RS10570 | 2146998..2147144 | + | 147 | Protein_1954 | transposase domain-containing protein | - |
| CNQ55_RS26350 | 2147433..2147546 | - | 114 | WP_001161660.1 | DUF957 domain-containing protein | - |
| CNQ55_RS10575 | 2147559..2147753 | - | 195 | WP_000988601.1 | hypothetical protein | - |
| CNQ55_RS10580 | 2147750..2148124 | - | 375 | WP_000854814.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| CNQ55_RS10585 | 2148213..2148566 | - | 354 | WP_198319677.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| CNQ55_RS10590 | 2148646..2148867 | - | 222 | WP_000692353.1 | DUF987 domain-containing protein | - |
| CNQ55_RS10595 | 2148936..2149412 | - | 477 | WP_001186199.1 | RadC family protein | - |
| CNQ55_RS10600 | 2149428..2149901 | - | 474 | WP_021552834.1 | antirestriction protein | - |
| CNQ55_RS10605 | 2150164..2150985 | - | 822 | WP_001234571.1 | DUF945 domain-containing protein | - |
| CNQ55_RS10615 | 2151206..2151616 | - | 411 | WP_000846704.1 | hypothetical protein | - |
| CNQ55_RS10620 | 2151632..2152309 | - | 678 | WP_001362823.1 | hypothetical protein | - |
| CNQ55_RS10625 | 2152445..2153515 | - | 1071 | WP_000102631.1 | patatin-like phospholipase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13898.94 Da Isoelectric Point: 7.8522
>T80873 WP_000854814.1 NZ_CP023357:c2148124-2147750 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T80873 NZ_CP023357:c2148124-2147750 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 118 a.a. Molecular weight: 13001.72 Da Isoelectric Point: 4.5538
>AT80873 WP_198319677.1 NZ_CP023357:c2148566-2148213 [Escherichia coli]
VSDTLPDDNNDSPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELSPR
YQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLPDDNNDSPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSGELSPR
YQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 354 bp
>AT80873 NZ_CP023357:c2148566-2148213 [Escherichia coli]
GTGTCAGACACACTCCCCGACGACAACAACGACAGCCCCTGGTGGGGACTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGTGAACTCAGCCCCCGC
TATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGACGACAACAACGACAGCCCCTGGTGGGGACTGCCCTGCACCGTGACGCCCTGTTTCGGCGC
CCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCTGTTCAGCGATGCAGATG
CGTACCACCTGGACCAGGCCTTTCCGTTGCTGATGAAACAACTGGAGCTCATGCTCACCAGTGGTGAACTCAGCCCCCGC
TATCAGCATACCGTCACGCTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTGTGGTTACGTTTATCT
GGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|