Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1786..2333 Replicon plasmid p72
Accession NZ_CP023355
Organism Escherichia coli strain 746

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag CNQ56_RS26325 Protein ID WP_000969996.1
Coordinates 2052..2333 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID F4V9S6
Locus tag CNQ56_RS26320 Protein ID WP_000079931.1
Coordinates 1786..2055 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ56_RS26305 13..870 + 858 WP_000130647.1 incFII family plasmid replication initiator RepA -
CNQ56_RS26320 1786..2055 + 270 WP_000079931.1 hypothetical protein Antitoxin
CNQ56_RS26325 2052..2333 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CNQ56_RS26330 2421..2768 + 348 WP_096035196.1 hypothetical protein -
CNQ56_RS26335 2788..3378 - 591 WP_096035197.1 hypothetical protein -
CNQ56_RS26340 3378..3635 - 258 WP_042077529.1 hypothetical protein -
CNQ56_RS26350 4203..4616 + 414 WP_000465036.1 hypothetical protein -
CNQ56_RS26355 4618..4878 + 261 Protein_8 tyrosine-type recombinase/integrase -
CNQ56_RS26360 5051..6259 - 1209 WP_000198533.1 IS91 family transposase -
CNQ56_RS26365 6240..6512 - 273 WP_000019163.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..72470 72470


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T80854 WP_000969996.1 NZ_CP023355:2052-2333 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T80854 NZ_CP023355:2052-2333 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10194.55 Da        Isoelectric Point: 8.8735

>AT80854 WP_000079931.1 NZ_CP023355:1786-2055 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT80854 NZ_CP023355:1786-2055 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCCTCTGCTGCAGCATGGCGGGAT
GAAATGAGCAGGAAGGTCGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9DLR5

References