Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 940326..941124 Replicon chromosome
Accession NZ_CP023353
Organism Escherichia coli strain 746

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag CNQ56_RS04825 Protein ID WP_000854735.1
Coordinates 940326..940703 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M1EW42
Locus tag CNQ56_RS04830 Protein ID WP_032153712.1
Coordinates 940750..941124 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CNQ56_RS04795 936294..937556 - 1263 WP_001596139.1 integrase arm-type DNA-binding domain-containing protein -
CNQ56_RS04800 938020..938346 - 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
CNQ56_RS04805 938343..938606 - 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
CNQ56_RS04810 938678..939544 - 867 WP_032153714.1 DUF4942 domain-containing protein -
CNQ56_RS04815 939629..939826 - 198 WP_000839265.1 DUF957 domain-containing protein -
CNQ56_RS04820 939838..940329 - 492 WP_023155722.1 hypothetical protein -
CNQ56_RS04825 940326..940703 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
CNQ56_RS04830 940750..941124 - 375 WP_032153712.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
CNQ56_RS04835 941204..941425 - 222 WP_000692345.1 DUF987 domain-containing protein -
CNQ56_RS04840 941494..941970 - 477 WP_001186715.1 RadC family protein -
CNQ56_RS04850 941986..942471 - 486 WP_032153711.1 antirestriction protein -
CNQ56_RS04855 942563..943381 - 819 WP_001234693.1 DUF945 domain-containing protein -
CNQ56_RS04860 943472..943681 - 210 WP_023155727.1 DUF905 family protein -
CNQ56_RS04865 943711..944388 - 678 WP_023155728.1 hypothetical protein -
CNQ56_RS04870 944507..945391 - 885 WP_024166630.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T80826 WP_000854735.1 NZ_CP023353:c940703-940326 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T80826 NZ_CP023353:c940703-940326 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13697.51 Da        Isoelectric Point: 6.6240

>AT80826 WP_032153712.1 NZ_CP023353:c941124-940750 [Escherichia coli]
VSDTLPGTTHPDDNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT80826 NZ_CP023353:c941124-940750 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A1M1EW42

References