Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipA3-mazE/HipA-MazE
Location 2950099..2951720 Replicon chromosome
Accession NZ_CP023315
Organism Caulobacter vibrioides strain CB13b1a

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag CA606_RS13965 Protein ID WP_096050575.1
Coordinates 2950413..2951720 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag CA606_RS13960 Protein ID WP_096050576.1
Coordinates 2950099..2950341 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA606_RS13935 2945226..2946596 - 1371 WP_096050581.1 hypothetical protein -
CA606_RS13940 2946756..2948153 - 1398 WP_096050580.1 sensor histidine kinase -
CA606_RS13945 2948284..2948961 - 678 WP_096050579.1 response regulator transcription factor -
CA606_RS13950 2948977..2949294 - 318 WP_096050578.1 PepSY domain-containing protein -
CA606_RS13955 2949423..2949932 - 510 WP_096050577.1 hypothetical protein -
CA606_RS13960 2950099..2950341 - 243 WP_096050576.1 PbsX family transcriptional regulator Antitoxin
CA606_RS13965 2950413..2951720 - 1308 WP_096050575.1 type II toxin-antitoxin system HipA family toxin Toxin
CA606_RS13970 2951717..2952076 - 360 WP_096050574.1 helix-turn-helix domain-containing protein -
CA606_RS13975 2952238..2953182 - 945 WP_096050573.1 J domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-116)

Antitoxin

Antitoxin PemI-like

(1-80)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47876.22 Da        Isoelectric Point: 6.4385

>T80736 WP_096050575.1 NZ_CP023315:c2951720-2950413 [Caulobacter vibrioides]
MTTVAEVRLWGSRIGAVSLEDGAETAAFAYEPGFLASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPDTNEVRSGQVEAGEGFGYWLLKFDGVSGNKDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLPMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWRLSPAFDITWSYNPDGDWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFEE
VREAVMRWPAFADAAGVDERWRDQIGATLRLELIR

Download         Length: 1308 bp

>T80736 NZ_CP023315:c2951720-2950413 [Caulobacter vibrioides]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGCATCGGCGCGGTGTCGCTGGAGGATGGCGCAGAGACGGCGGC
CTTCGCCTATGAGCCGGGCTTTCTCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCGGGCGTGTTCA
GCTTTCCCGACCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAGGGGCGCAGCCCTGAAAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGCCGCCGGGTGTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCTTCGGAGGTTCTGACCCATCGCCATGACCTGCGGGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCCTGAGCGTCGGCACCTCGGCGGGCGGGGCTCGGGCCAAGGCGGTGATCGCCTGGAATCCCGACAC
GAACGAAGTCCGCTCCGGCCAGGTCGAGGCCGGCGAGGGCTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTTTCCGGCA
ACAAGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGGCAGATGGCGGCGGCGGCGGGG
ATCGACGTCGCCGAGAGTCGTCTGCTGGAGGAGGGCGGTCGCCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCCCTGGCCGCCATCGCCCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAGC
AGGCCCTGTTCACGATGCGGCGGATGGGCTTGCCGATGGCGCAGCTGGAGGAGCAATTCCGGCGCATGGTCTTCAACGTG
CTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTTCTGATGGACCGCGCCGGGCGCTGGCGCCTGTCGCCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGACTGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTGGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGCGGTCACGTCGGCCGGATCTTCGAGGAG
GTGCGGGAGGCCGTGATGCGGTGGCCCGCCTTCGCCGACGCGGCCGGGGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
GACGCTGCGGCTGGAGCTCATCCGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8842.12 Da        Isoelectric Point: 4.1954

>AT80736 WP_096050576.1 NZ_CP023315:c2950341-2950099 [Caulobacter vibrioides]
MQVIIEKRGGGAWLRIPETVVAATSIEIGQSVDVREENGRIIIEPIRASAYDLGVMLADMKPETFPEEVDFGARIGNEVW

Download         Length: 243 bp

>AT80736 NZ_CP023315:c2950341-2950099 [Caulobacter vibrioides]
ATGCAGGTCATCATCGAAAAGCGGGGCGGCGGCGCCTGGCTCCGCATCCCGGAGACCGTTGTGGCGGCGACATCAATCGA
GATCGGTCAGTCCGTGGATGTGCGCGAAGAGAACGGCCGGATCATCATCGAGCCGATCCGCGCCTCCGCTTATGATCTTG
GCGTGATGCTCGCTGACATGAAGCCGGAGACCTTCCCTGAGGAGGTCGATTTTGGCGCGCGCATCGGCAACGAGGTCTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References