Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 896247..896800 Replicon chromosome
Accession NZ_CP023315
Organism Caulobacter vibrioides strain CB13b1a

Toxin (Protein)


Gene name parE Uniprot ID Q9A9T8
Locus tag CA606_RS04230 Protein ID WP_010918758.1
Coordinates 896247..896537 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58091
Locus tag CA606_RS04235 Protein ID WP_010918759.1
Coordinates 896534..896800 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA606_RS04205 891883..892764 - 882 WP_096052249.1 endonuclease/exonuclease/phosphatase family protein -
CA606_RS04210 892864..893931 - 1068 WP_181242782.1 serine hydrolase -
CA606_RS04215 893981..894751 - 771 WP_096052248.1 hypothetical protein -
CA606_RS04220 894830..895357 - 528 WP_096052247.1 GNAT family N-acetyltransferase -
CA606_RS04225 895491..896246 + 756 WP_096053878.1 MOSC N-terminal beta barrel domain-containing protein -
CA606_RS04230 896247..896537 - 291 WP_010918758.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA606_RS04235 896534..896800 - 267 WP_010918759.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CA606_RS04240 896875..897744 + 870 WP_096052246.1 peptide chain release factor N(5)-glutamine methyltransferase -
CA606_RS04245 897782..898006 + 225 Protein_840 hypothetical protein -
CA606_RS04250 898003..899079 + 1077 WP_096052245.1 DUF4167 domain-containing protein -
CA606_RS04255 899366..900121 + 756 WP_096053877.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(2-81)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11057.55 Da        Isoelectric Point: 8.9111

>T80734 WP_010918758.1 NZ_CP023315:c896537-896247 [Caulobacter vibrioides]
MKPYRLSRRAKADLDDIWTYSEQRWGVEQAADYARELQATIEMIAEHPGMGQPDENLRAGYRRCASGSHVVFYRVGVRVE
IIRVLHQSMNARAHLG

Download         Length: 291 bp

>T80734 NZ_CP023315:c896537-896247 [Caulobacter vibrioides]
ATGAAGCCCTATCGGCTATCCCGTCGCGCCAAAGCCGACCTCGATGACATCTGGACCTATTCGGAGCAGCGATGGGGCGT
TGAACAAGCCGCCGACTACGCCCGTGAACTGCAGGCCACCATCGAGATGATCGCTGAACATCCGGGTATGGGACAGCCGG
ATGAAAACCTCCGTGCGGGCTACAGGCGATGCGCCAGCGGCTCGCACGTGGTCTTTTACCGCGTCGGCGTCCGGGTGGAG
ATTATCCGCGTGCTACACCAAAGCATGAACGCCAGGGCTCACCTTGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9635.57 Da        Isoelectric Point: 4.1523

>AT80734 WP_010918759.1 NZ_CP023315:c896800-896534 [Caulobacter vibrioides]
MASKNTSVVLGDHFQAFIDSQVADGRYGSASEVIRAGLRLLEENEAKLAALRAALIEGEESGFIEDFDFDAFIEERSRAS
APQGFHEE

Download         Length: 267 bp

>AT80734 NZ_CP023315:c896800-896534 [Caulobacter vibrioides]
ATGGCGAGCAAGAACACCTCCGTCGTCCTGGGCGATCACTTCCAGGCGTTCATCGACAGCCAGGTCGCTGACGGGCGCTA
CGGCTCGGCCAGCGAAGTCATCCGCGCGGGGCTGAGGCTCCTCGAAGAGAACGAAGCGAAGCTCGCGGCCCTCCGCGCCG
CCCTGATCGAAGGCGAGGAGAGCGGCTTTATCGAGGACTTCGACTTCGACGCCTTTATCGAGGAAAGGTCTAGGGCATCC
GCTCCACAGGGGTTCCATGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3KXE

Antitoxin

Source ID Structure
PDB 3KXE
AlphaFold DB A0A290N011

References