Detailed information of TA system TA080732

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 607084..607672
• Replicon: chromosome
• Accession: NZ_CP023315
• Organism: Caulobacter vibrioides strain CB13b1a

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: Q9A3L9
• Locus tag: CA606_RS02965
• Protein ID: WP_010921020.1
• Coordinates: 607484..607672 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: CA606_RS02960
• Protein ID: WP_096052459.1
• Coordinates: 607084..607479 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA606_RS02945	603842..605398	+	1557	WP_096052462.1	acyl--CoA ligase	-
CA606_RS02950	605526..606524	+	999	WP_096052461.1	DegT/DnrJ/EryC1/StrS aminotransferase family protein	-
CA606_RS02955	606575..607075	+	501	WP_096052460.1	DUF2199 domain-containing protein	-
CA606_RS02960	607084..607479	-	396	WP_096052459.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
CA606_RS02965	607484..607672	-	189	WP_010921020.1	type II toxin-antitoxin system HicA family toxin	Toxin
CA606_RS02970	607726..608694	-	969	WP_096052458.1	magnesium/cobalt transporter CorA	-
CA606_RS02975	608705..609739	-	1035	WP_096052457.1	adenosine deaminase	-
CA606_RS02980	609938..610957	+	1020	WP_096052456.1	amidohydrolase family protein	-
CA606_RS02985	611131..612138	+	1008	WP_096052455.1	photosystem II stability/assembly factor-like protein	-
CA606_RS02990	612181..612339	+	159	WP_096052454.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-124)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 6984.02 Da
• Isoelectric Point: 11.4778

>T80732 WP_010921020.1 NZ_CP023315:c607672-607484 [Caulobacter vibrioides]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR

Nucleotide

• Length: 189 bp

>T80732 NZ_CP023315:c607672-607484 [Caulobacter vibrioides]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGCTCTCACGCGCAATT
CAAGCACCCGACCAAGTCCGGACGCGTGACCGTGCCGCACCCCAAGCGCGACTTGCCGCTGGGAACGCTGCGCTCGATCG
AGCGTCAGGCAGACCTGAAACTGAGGTAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 13892.75 Da
• Isoelectric Point: 4.2521

>AT80732 WP_096052459.1 NZ_CP023315:c607479-607084 [Caulobacter vibrioides]
MADYIALIHKDAESAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGEALPAPSALDEVMANPGNRDGVVIL
VPLKTAQPRTVRVNITLPETTLREIDAFAETHGYTRSGLLARAAKQLIDAA

Nucleotide

• Length: 396 bp

>AT80732 NZ_CP023315:c607479-607084 [Caulobacter vibrioides]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGAGAGCGCCTTCGGTGTGTCCTTTCCCGACTTGCCGGGCTGCAT
CAGCGTCGGCGAGACGCTTGAAGAAGCCCGCGCCAACGCCGAGGAGGCTCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAGCCCTGCCGGCGCCGTCAGCCCTGGACGAGGTCATGGCCAACCCCGGCAACCGCGACGGCGTGGTGATCCTT
GTGCCGCTGAAGACCGCCCAGCCCCGGACGGTGCGGGTCAACATCACCTTGCCCGAGACCACGCTGCGCGAAATCGACGC
CTTCGCCGAAACCCATGGCTATACGCGTTCAGGTCTTCTGGCGCGCGCCGCCAAGCAGCTGATCGACGCCGCTTAA

Structures

Toxin

• AlphaFold DB: A0A290MM32