Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagD-vapB/LOTUS_5_Limkain_b1-VagC
Location 365823..366499 Replicon chromosome
Accession NZ_CP023315
Organism Caulobacter vibrioides strain CB13b1a

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag CA606_RS01745 Protein ID WP_181242734.1
Coordinates 366092..366499 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CA606_RS01740 Protein ID WP_096052674.1
Coordinates 365823..366095 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA606_RS01725 361082..364045 + 2964 WP_096052677.1 2-oxoglutarate dehydrogenase E1 component -
CA606_RS01730 364105..365325 + 1221 WP_096052676.1 2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase -
CA606_RS01735 365420..365764 + 345 WP_096052675.1 DUF3088 family protein -
CA606_RS01740 365823..366095 + 273 WP_096052674.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
CA606_RS01745 366092..366499 + 408 WP_181242734.1 type II toxin-antitoxin system VapC family toxin Toxin
CA606_RS01750 366979..368379 + 1401 WP_096052671.1 dihydrolipoyl dehydrogenase -
CA606_RS01755 368473..368829 + 357 WP_097563457.1 hypothetical protein -
CA606_RS01760 369006..371027 - 2022 WP_096052669.1 methyl-accepting chemotaxis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-126)

Antitoxin

SpoVT-AbrB domain

(14-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14780.89 Da        Isoelectric Point: 6.7307

>T80731 WP_181242734.1 NZ_CP023315:366092-366499 [Caulobacter vibrioides]
VTLALDTNVFIDLLRGRRASVRQRHAEAILGTRPLVTSLVVFHELHFGIAASPNSVAEADAVAIVLRGVSIEPLTEQDMI
RAAEVRARLRRTGRPIGGYDGLIAGQALERGWTLVTSNVREFDRVEGLALENWGE

Download         Length: 408 bp

>T80731 NZ_CP023315:366092-366499 [Caulobacter vibrioides]
GTGACCCTAGCACTCGACACGAACGTCTTTATCGACCTGCTGCGGGGACGTCGCGCCTCCGTGCGCCAGAGACATGCCGA
AGCGATCCTCGGAACTCGGCCGCTGGTGACGTCTCTGGTGGTGTTCCACGAGCTGCATTTCGGAATAGCGGCCAGCCCGA
ACAGCGTTGCGGAGGCCGATGCGGTAGCGATCGTCCTCAGGGGCGTTTCCATCGAGCCCTTAACCGAGCAAGACATGATC
CGAGCGGCGGAGGTCCGGGCGCGCTTGAGGCGTACGGGCCGACCGATCGGTGGGTACGATGGGCTGATCGCGGGCCAAGC
CCTCGAGCGCGGTTGGACGCTTGTCACATCCAATGTTCGTGAATTCGATCGCGTCGAAGGGCTCGCGCTTGAGAACTGGG
GCGAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10334.69 Da        Isoelectric Point: 5.8992

>AT80731 WP_096052674.1 NZ_CP023315:365823-366095 [Caulobacter vibrioides]
MAKIDVEPARAKLFTHGGSQAVRLPKAFRFDGTEVTVRREGRKVILEPLTDDRPRTRAELEAMWARVDTLLGGEFPDRDQ
PPEQERDFGW

Download         Length: 273 bp

>AT80731 NZ_CP023315:365823-366095 [Caulobacter vibrioides]
ATGGCCAAGATCGACGTCGAACCTGCCCGCGCAAAGCTCTTCACCCATGGTGGCAGCCAAGCCGTACGCTTGCCGAAAGC
CTTTCGGTTTGACGGGACCGAGGTCACGGTCAGGCGTGAAGGGCGGAAGGTGATCCTCGAGCCACTGACGGATGACCGTC
CCCGGACTCGGGCTGAACTTGAGGCCATGTGGGCGCGCGTTGACACGCTTCTCGGCGGTGAGTTCCCGGATCGGGATCAG
CCCCCTGAACAAGAGCGCGATTTCGGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References