Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA-HicB |
Location | 3551182..3551770 | Replicon | chromosome |
Accession | NZ_CP023314 | ||
Organism | Caulobacter vibrioides strain CB1 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | Q9A3L9 |
Locus tag | CA607_RS17425 | Protein ID | WP_010921020.1 |
Coordinates | 3551182..3551370 (+) | Length | 63 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | Q9A3L8 |
Locus tag | CA607_RS17430 | Protein ID | WP_010921021.1 |
Coordinates | 3551375..3551770 (+) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CA607_RS17400 | 3547066..3548085 | - | 1020 | WP_024265922.1 | amidohydrolase family protein | - |
CA607_RS17405 | 3548261..3549295 | + | 1035 | WP_010921016.1 | adenosine deaminase | - |
CA607_RS17410 | 3549306..3550274 | + | 969 | WP_010921017.1 | magnesium and cobalt transport protein CorA | - |
CA607_RS17415 | 3550252..3550803 | - | 552 | WP_010921018.1 | hypothetical protein | - |
CA607_RS17420 | 3550800..3551105 | - | 306 | WP_010921019.1 | PadR family transcriptional regulator | - |
CA607_RS17425 | 3551182..3551370 | + | 189 | WP_010921020.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
CA607_RS17430 | 3551375..3551770 | + | 396 | WP_010921021.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
CA607_RS17435 | 3551779..3552255 | - | 477 | WP_010921022.1 | DUF2199 domain-containing protein | - |
CA607_RS17440 | 3552313..3553311 | - | 999 | WP_010921023.1 | DegT/DnrJ/EryC1/StrS aminotransferase family protein | - |
CA607_RS17445 | 3553439..3554992 | - | 1554 | WP_010921024.1 | acyl--CoA ligase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 6984.02 Da Isoelectric Point: 11.4778
>T80730 WP_010921020.1 NZ_CP023314:3551182-3551370 [Caulobacter vibrioides]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR
Download Length: 189 bp
>T80730 NZ_CP023314:3551182-3551370 [Caulobacter vibrioides]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCAACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGTGACTTGCCGCTAGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCAACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGTGACTTGCCGCTAGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG
Antitoxin
Download Length: 132 a.a. Molecular weight: 13937.84 Da Isoelectric Point: 4.1587
>AT80730 WP_010921021.1 NZ_CP023314:3551375-3551770 [Caulobacter vibrioides]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA
Download Length: 396 bp
>AT80730 NZ_CP023314:3551375-3551770 [Caulobacter vibrioides]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCCCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCCCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A290MM32 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | Q9A3L8 |