Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3551182..3551770 Replicon chromosome
Accession NZ_CP023314
Organism Caulobacter vibrioides strain CB1

Toxin (Protein)


Gene name hicA Uniprot ID Q9A3L9
Locus tag CA607_RS17425 Protein ID WP_010921020.1
Coordinates 3551182..3551370 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9A3L8
Locus tag CA607_RS17430 Protein ID WP_010921021.1
Coordinates 3551375..3551770 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA607_RS17400 3547066..3548085 - 1020 WP_024265922.1 amidohydrolase family protein -
CA607_RS17405 3548261..3549295 + 1035 WP_010921016.1 adenosine deaminase -
CA607_RS17410 3549306..3550274 + 969 WP_010921017.1 magnesium and cobalt transport protein CorA -
CA607_RS17415 3550252..3550803 - 552 WP_010921018.1 hypothetical protein -
CA607_RS17420 3550800..3551105 - 306 WP_010921019.1 PadR family transcriptional regulator -
CA607_RS17425 3551182..3551370 + 189 WP_010921020.1 type II toxin-antitoxin system HicA family toxin Toxin
CA607_RS17430 3551375..3551770 + 396 WP_010921021.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CA607_RS17435 3551779..3552255 - 477 WP_010921022.1 DUF2199 domain-containing protein -
CA607_RS17440 3552313..3553311 - 999 WP_010921023.1 DegT/DnrJ/EryC1/StrS aminotransferase family protein -
CA607_RS17445 3553439..3554992 - 1554 WP_010921024.1 acyl--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6984.02 Da        Isoelectric Point: 11.4778

>T80730 WP_010921020.1 NZ_CP023314:3551182-3551370 [Caulobacter vibrioides]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR

Download         Length: 189 bp

>T80730 NZ_CP023314:3551182-3551370 [Caulobacter vibrioides]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCAACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGTGACTTGCCGCTAGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13937.84 Da        Isoelectric Point: 4.1587

>AT80730 WP_010921021.1 NZ_CP023314:3551375-3551770 [Caulobacter vibrioides]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA

Download         Length: 396 bp

>AT80730 NZ_CP023314:3551375-3551770 [Caulobacter vibrioides]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCCCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290MM32

Antitoxin

Source ID Structure
AlphaFold DB Q9A3L8

References