Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/-
Location 3491562..3492004 Replicon chromosome
Accession NZ_CP023314
Organism Caulobacter vibrioides strain CB1

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3CB57
Locus tag CA607_RS17145 Protein ID WP_012640672.1
Coordinates 3491729..3492004 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID P0CW75
Locus tag CA607_RS17140 Protein ID WP_012640671.1
Coordinates 3491562..3491741 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA607_RS17125 3486620..3488641 - 2022 WP_010920964.1 tetratricopeptide repeat-containing sulfotransferase family protein -
CA607_RS17130 3488724..3490013 - 1290 WP_010920965.1 FAD-binding oxidoreductase -
CA607_RS17135 3490089..3491486 - 1398 WP_010920966.1 glutamine synthetase family protein -
CA607_RS17140 3491562..3491741 + 180 WP_012640671.1 antitoxin RelB4 Antitoxin
CA607_RS17145 3491729..3492004 + 276 WP_012640672.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA607_RS17150 3492007..3493410 - 1404 WP_010920968.1 aspartate aminotransferase family protein -
CA607_RS17155 3493428..3494177 - 750 WP_012640673.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
CA607_RS17160 3494182..3495327 - 1146 WP_010920970.1 ABC transporter ATP-binding protein -
CA607_RS17165 3495473..3496348 - 876 WP_012640674.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-89)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10141.74 Da        Isoelectric Point: 11.9574

>T80729 WP_012640672.1 NZ_CP023314:3491729-3492004 [Caulobacter vibrioides]
VAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVI
GSVRHGARRPI

Download         Length: 276 bp

>T80729 NZ_CP023314:3491729-3492004 [Caulobacter vibrioides]
GTGGCGCAAGTAGTCTGGACCCAACGAGCGATGGCCGATGTTTACGCCATCGTCGGCCATATCTCCGAGCAGTCGCGTCC
TCTCGCGGCCCAGCGCCTGGCCAAGAGGTTGTTCGACACCGGCGCTAGCCTGGCGACCTATCCCGAACGCGGGCGCGTGA
GCACTCAAGGACGGCGTGAGATCGTCGCGATTTCGCCCTACGTTCTGCGCTACCGCATTGTCGGCGACCGTGTCGTCATT
GGCAGCGTACGCCATGGGGCGCGTCGACCTATCTAG

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6606.17 Da        Isoelectric Point: 3.9689

>AT80729 WP_012640671.1 NZ_CP023314:3491562-3491741 [Caulobacter vibrioides]
MAEPDPDIFDEDDEAILAADAEADADFEAGRTVPHERVGEWLKTLGTPHQTPPPYSWRK

Download         Length: 180 bp

>AT80729 NZ_CP023314:3491562-3491741 [Caulobacter vibrioides]
ATGGCCGAGCCTGACCCCGACATCTTCGACGAGGACGATGAAGCGATCCTGGCGGCTGACGCCGAGGCTGACGCCGACTT
CGAAGCCGGTAGAACTGTTCCGCACGAGCGTGTGGGCGAGTGGCTCAAGACGTTGGGCACGCCGCACCAGACACCGCCAC
CATATTCGTGGCGCAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3CB57

Antitoxin

Source ID Structure
AlphaFold DB P0CW75

References