Detailed information of TA system TA080728

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3104423..3106086
• Replicon: chromosome
• Accession: NZ_CP023314
• Organism: Caulobacter vibrioides strain CB1

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: Q9A4R0
• Locus tag: CA607_RS15210
• Protein ID: WP_010920611.1
• Coordinates: 3104423..3105730 (-)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: CA607_RS15215
• Protein ID: WP_010920612.1
• Coordinates: 3105727..3106086 (-)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA607_RS15180	3099511..3100881	-	1371	WP_012640579.1	hypothetical protein	-
CA607_RS15185	3101042..3102439	-	1398	WP_010920606.1	sensor histidine kinase	-
CA607_RS15190	3102570..3103247	-	678	WP_010920607.1	response regulator transcription factor	-
CA607_RS15195	3103266..3103583	-	318	WP_010920608.1	PepSY domain-containing protein	-
CA607_RS15200	3103712..3104221	-	510	WP_010920609.1	hypothetical protein	-
CA607_RS15210	3104423..3105730	-	1308	WP_010920611.1	type II toxin-antitoxin system HipA family toxin	Toxin
CA607_RS15215	3105727..3106086	-	360	WP_010920612.1	helix-turn-helix domain-containing protein	Antitoxin
CA607_RS15220	3106249..3107193	-	945	WP_012640580.1	J domain-containing protein	-
CA607_RS15225	3107282..3110992	-	3711	WP_205685721.1	glycoside hydrolase TIM-barrel-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (170-407)

Antitoxin

• Cro/C1-type helix-turn-helix domain (17-67)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 47909.26 Da
• Isoelectric Point: 6.8907

>T80728 WP_010920611.1 NZ_CP023314:c3105730-3104423 [Caulobacter vibrioides]
MTTVAEVRLWGSRIGAVSLEDGAETAVFAYEPSFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLSMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWRLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFDE
VREAVMRWPTFADAAGVDERWRDQIGATVRLELRR

Nucleotide

• Length: 1308 bp

>T80728 NZ_CP023314:c3105730-3104423 [Caulobacter vibrioides]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCAGTGTCGCTGGAGGACGGCGCGGAGACGGCGGT
CTTCGCCTATGAGCCGAGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCCTCTGAGGTTCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCGAC
CAACGAGGTGCGCTCCGGCCAGGTCGAGGCCGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCCCTGGCCGCCATCGCTCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAGC
AGGCCCTGTTCACCATGCGGCGGATGGGCTTGTCGATGGCGCAGCTGGAGGAGCAGTTCCGGCGCATGGTCTTCAACGTG
CTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCCGGACGCTGGCGCCTGTCGCCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTCGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGTGGTCACGTCGGCCGGATTTTCGATGAG
GTGCGGGAGGCCGTGATGCGGTGGCCGACCTTCGCCGACGCGGCCGGGGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
TACGGTGCGGCTGGAGCTCAGGCGGTAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13019.91 Da
• Isoelectric Point: 10.1741

>AT80728 WP_010920612.1 NZ_CP023314:c3106086-3105727 [Caulobacter vibrioides]
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK

Nucleotide

• Length: 360 bp

>AT80728 NZ_CP023314:c3106086-3105727 [Caulobacter vibrioides]
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTATCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCCTGGGTGTGGGGCGATGAAAAATGA

Structures

Toxin

• AlphaFold DB: Q9A4R0