Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 994901..995454 Replicon chromosome
Accession NZ_CP023314
Organism Caulobacter vibrioides strain CB1

Toxin (Protein)


Gene name parE Uniprot ID Q9A9T8
Locus tag CA607_RS04735 Protein ID WP_010918758.1
Coordinates 994901..995191 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58091
Locus tag CA607_RS04740 Protein ID WP_010918759.1
Coordinates 995188..995454 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA607_RS04705 990268..991458 - 1191 WP_010918752.1 erythromycin esterase family protein -
CA607_RS04710 991521..992111 - 591 WP_010918753.1 AAA family ATPase -
CA607_RS04715 992108..993175 - 1068 WP_012640075.1 serine hydrolase -
CA607_RS04720 993225..993401 - 177 WP_010918755.1 hypothetical protein -
CA607_RS04725 993480..994007 - 528 WP_012640076.1 GNAT family N-acetyltransferase -
CA607_RS04730 994139..994900 + 762 WP_024265642.1 MOSC domain-containing protein -
CA607_RS04735 994901..995191 - 291 WP_010918758.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CA607_RS04740 995188..995454 - 267 WP_010918759.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
CA607_RS04745 995528..996397 + 870 WP_012640077.1 peptide chain release factor N(5)-glutamine methyltransferase -
CA607_RS04750 996435..996659 + 225 WP_012640078.1 hypothetical protein -
CA607_RS04755 996656..997768 + 1113 WP_010918761.1 DUF4167 domain-containing protein -
CA607_RS04760 997936..998691 + 756 WP_010918762.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin

Antitoxin ParD

(2-81)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11057.55 Da        Isoelectric Point: 8.9111

>T80726 WP_010918758.1 NZ_CP023314:c995191-994901 [Caulobacter vibrioides]
MKPYRLSRRAKADLDDIWTYSEQRWGVEQAADYARELQATIEMIAEHPGMGQPDENLRAGYRRCASGSHVVFYRVGVRVE
IIRVLHQSMNARAHLG

Download         Length: 291 bp

>T80726 NZ_CP023314:c995191-994901 [Caulobacter vibrioides]
ATGAAGCCCTATCGGCTATCCCGTCGCGCCAAGGCCGACCTCGATGACATCTGGACCTATTCAGAGCAGCGATGGGGCGT
TGAACAAGCCGCCGACTACGCCCGTGAACTGCAGGCCACCATCGAGATGATCGCTGAACATCCGGGTATGGGACAGCCGG
ATGAAAACCTCCGCGCGGGCTACAGGCGATGCGCCAGCGGCTCGCACGTGGTCTTTTACCGCGTCGGCGTGCGGGTCGAG
ATTATCCGCGTGCTACACCAAAGCATGAACGCCAGGGCTCACCTTGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9635.57 Da        Isoelectric Point: 4.1523

>AT80726 WP_010918759.1 NZ_CP023314:c995454-995188 [Caulobacter vibrioides]
MASKNTSVVLGDHFQAFIDSQVADGRYGSASEVIRAGLRLLEENEAKLAALRAALIEGEESGFIEDFDFDAFIEERSRAS
APQGFHEE

Download         Length: 267 bp

>AT80726 NZ_CP023314:c995454-995188 [Caulobacter vibrioides]
ATGGCGAGCAAGAACACCTCCGTCGTCCTGGGCGATCACTTCCAGGCGTTCATCGACAGCCAGGTCGCTGACGGGCGCTA
CGGCTCGGCCAGCGAAGTCATCCGCGCGGGGCTGAGGCTCCTCGAAGAGAACGAAGCGAAGCTCGCGGCCCTCCGCGCCG
CCCTGATCGAAGGCGAGGAGAGCGGCTTTATCGAGGACTTCGACTTCGACGCCTTTATCGAGGAAAGGTCTAGGGCATCC
GCTCCGCAGGGGTTCCATGAGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3KXE

Antitoxin

Source ID Structure
PDB 3KXE
AlphaFold DB A0A290N011

References