Detailed information of TA system TA080725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 916914..917455
• Replicon: chromosome
• Accession: NZ_CP023314
• Organism: Caulobacter vibrioides strain CB1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q9AA09
• Locus tag: CA607_RS04370
• Protein ID: WP_010918687.1
• Coordinates: 916914..917195 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9AA08
• Locus tag: CA607_RS04375
• Protein ID: WP_010918688.1
• Coordinates: 917192..917455 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA607_RS04355	911996..913612	-	1617	WP_012640065.1	carboxylesterase/lipase family protein	-
CA607_RS04360	913702..915426	-	1725	WP_010918685.1	hypothetical protein	-
CA607_RS04365	915510..916838	-	1329	WP_010918686.1	mannanase	-
CA607_RS04370	916914..917195	-	282	WP_010918687.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CA607_RS04375	917192..917455	-	264	WP_010918688.1	type II toxin-antitoxin system antitoxin RelB1	Antitoxin
CA607_RS04380	917494..920583	-	3090	WP_010918689.1	bifunctional proline dehydrogenase/L-glutamate gamma-semialdehyde dehydrogenase PutA	-
CA607_RS04385	920668..920829	+	162	WP_024265629.1	hypothetical protein	-
CA607_RS04390	921029..921496	+	468	WP_010918690.1	Lrp/AsnC ligand binding domain-containing protein	-
CA607_RS04395	921523..921687	-	165	WP_024265630.1	leucine-responsive regulatory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10486.14 Da
• Isoelectric Point: 11.7926

>T80725 WP_010918687.1 NZ_CP023314:c917195-916914 [Caulobacter vibrioides]
MTFTVLVSVRAKRDFNRLIVWLVERDPRAAARLGPLLEAALDSLTEAPSRGRSVGPTTREISIPFGQSAYVIRYRLLGSS
VHVTRIWHGLEQR

Nucleotide

• Length: 282 bp

>T80725 NZ_CP023314:c917195-916914 [Caulobacter vibrioides]
TTGACCTTCACGGTTTTGGTATCCGTTCGGGCCAAGAGAGACTTCAACCGTCTCATCGTCTGGCTTGTGGAGCGCGACCC
CCGAGCAGCGGCTAGACTGGGCCCACTTCTGGAGGCCGCCCTCGACAGTTTGACCGAGGCGCCATCGCGAGGTCGCTCGG
TTGGTCCCACCACCCGCGAGATCAGCATTCCTTTTGGTCAGAGCGCCTATGTGATCCGCTACCGGCTCCTCGGCTCCAGC
GTACATGTCACCCGGATCTGGCACGGCCTTGAGCAAAGGTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9198.31 Da
• Isoelectric Point: 4.2560

>AT80725 WP_010918688.1 NZ_CP023314:c917455-917192 [Caulobacter vibrioides]
MADGFDIHIDQEQAARLKVVADRLGMSVSEYAVALIDAGLTGAAPKAIDPDPAIDEAIADAIERGDEPAISRDEFRAHIR
RVTAGLG

Nucleotide

• Length: 264 bp

>AT80725 NZ_CP023314:c917455-917192 [Caulobacter vibrioides]
ATGGCCGATGGCTTCGACATTCATATCGATCAAGAGCAGGCCGCCCGGCTGAAGGTCGTTGCCGACCGCCTGGGTATGTC
CGTGTCCGAGTACGCCGTTGCGCTGATCGACGCAGGGCTGACAGGCGCGGCGCCTAAAGCGATCGATCCGGACCCCGCCA
TCGACGAGGCCATCGCCGACGCCATCGAGCGGGGCGACGAGCCGGCGATTTCACGCGATGAGTTCCGCGCTCATATACGT
CGCGTGACTGCGGGCCTGGGTTGA

Structures

Toxin

• AlphaFold DB: Q9AA09

Antitoxin

• AlphaFold DB: Q9AA08