Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3497699..3498287 Replicon chromosome
Accession NZ_CP023313
Organism Caulobacter vibrioides strain CB2

Toxin (Protein)


Gene name hicA Uniprot ID Q9A3L9
Locus tag CA608_RS17035 Protein ID WP_010921020.1
Coordinates 3497699..3497887 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q9A3L8
Locus tag CA608_RS17040 Protein ID WP_010921021.1
Coordinates 3497892..3498287 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA608_RS17005 3493626..3494057 + 432 WP_096034296.1 RusA family crossover junction endodeoxyribonuclease -
CA608_RS17010 3494057..3494719 + 663 WP_096034297.1 DUF86 domain-containing protein -
CA608_RS17015 3494778..3495812 + 1035 WP_096034298.1 adenosine deaminase -
CA608_RS17020 3495823..3496791 + 969 WP_096034299.1 magnesium and cobalt transport protein CorA -
CA608_RS17025 3496769..3497320 - 552 WP_096034300.1 transporter -
CA608_RS17030 3497317..3497622 - 306 WP_010921019.1 PadR family transcriptional regulator -
CA608_RS17035 3497699..3497887 + 189 WP_010921020.1 type II toxin-antitoxin system HicA family toxin Toxin
CA608_RS17040 3497892..3498287 + 396 WP_010921021.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CA608_RS17045 3498296..3498772 - 477 WP_096034301.1 DUF2199 domain-containing protein -
CA608_RS17050 3498830..3499828 - 999 WP_096034302.1 DegT/DnrJ/EryC1/StrS aminotransferase family protein -
CA608_RS17055 3499956..3501509 - 1554 WP_096034303.1 acyl--CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6984.02 Da        Isoelectric Point: 11.4778

>T80722 WP_010921020.1 NZ_CP023313:3497699-3497887 [Caulobacter vibrioides]
MNSREVIAALEADGWVEVARRGSHAQFKHPTKSGRVTVPHPKRDLPLGTLRSIERQADLKLR

Download         Length: 189 bp

>T80722 NZ_CP023313:3497699-3497887 [Caulobacter vibrioides]
ATGAACAGTCGTGAGGTGATCGCGGCGCTGGAAGCCGATGGCTGGGTCGAAGTCGCACGGCGCGGTTCTCATGCGCAGTT
CAAGCACCCGACCAAGTCCGGGCGCGTGACCGTGCCGCACCCCAAGCGCGACTTGCCGCTGGGAACCCTGCGCTCGATCG
AGCGTCAGGCCGACCTGAAACTGAGGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 13937.84 Da        Isoelectric Point: 4.1587

>AT80722 WP_010921021.1 NZ_CP023313:3497892-3498287 [Caulobacter vibrioides]
MADYIALIHKDADSAFGVSFPDLPGCISVGETLEEARANAEEALALHVEGMIEDGETLPAPSALDEVMAAPGNRDGVVIL
VPLKTVQPRTVRVNITLPETTLREIDAFAETYGYTRSGLLARAAKQMIDAA

Download         Length: 396 bp

>AT80722 NZ_CP023313:3497892-3498287 [Caulobacter vibrioides]
ATGGCCGACTATATCGCCCTGATCCACAAGGACGCCGACAGCGCCTTCGGCGTATCTTTTCCCGACCTGCCCGGCTGTAT
CAGCGTCGGCGAGACGCTGGAAGAAGCCCGCGCCAACGCCGAGGAGGCCCTGGCGCTGCATGTCGAGGGCATGATCGAGG
ATGGCGAAACCCTGCCGGCGCCGTCCGCCCTGGACGAAGTCATGGCAGCCCCCGGCAACCGCGACGGTGTGGTGATCCTT
GTGCCGCTGAAGACCGTCCAGCCTCGGACGGTGCGGGTCAATATCACCTTACCCGAGACCACACTGCGCGAGATCGACGC
CTTCGCCGAAACCTATGGCTACACGCGTTCGGGTCTGCTGGCCCGCGCCGCCAAGCAGATGATCGACGCTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A290MM32

Antitoxin

Source ID Structure
AlphaFold DB Q9A3L8

References