Detailed information of TA system TA080721

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/-
• Location: 3437149..3437591
• Replicon: chromosome
• Accession: NZ_CP023313
• Organism: Caulobacter vibrioides strain CB2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CA608_RS16750
• Protein ID: WP_205685753.1
• Coordinates: 3437316..3437591 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: P0CW75
• Locus tag: CA608_RS16745
• Protein ID: WP_012640671.1
• Coordinates: 3437149..3437328 (+)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA608_RS16730	3432207..3434228	-	2022	WP_096034260.1	tetratricopeptide repeat-containing sulfotransferase family protein	-
CA608_RS16735	3434311..3435600	-	1290	WP_096034261.1	FAD-binding oxidoreductase	-
CA608_RS16740	3435676..3437073	-	1398	WP_010920966.1	glutamine synthetase family protein	-
CA608_RS16745	3437149..3437328	+	180	WP_012640671.1	antitoxin RelB4	Antitoxin
CA608_RS16750	3437316..3437591	+	276	WP_205685753.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CA608_RS16755	3437594..3438997	-	1404	WP_096034263.1	aspartate aminotransferase family protein	-
CA608_RS16760	3439015..3439767	-	753	WP_096034264.1	gamma-glutamyl-gamma-aminobutyrate hydrolase family protein	-
CA608_RS16765	3439928..3441067	-	1140	WP_096034265.1	ABC transporter ATP-binding protein	-
CA608_RS16770	3441228..3442085	-	858	WP_096034266.1	ABC transporter permease	-
CA608_RS16775	3442102..3442224	-	123	Protein_3259	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-89)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10141.74 Da
• Isoelectric Point: 11.9574

>T80721 WP_205685753.1 NZ_CP023313:3437316-3437591 [Caulobacter vibrioides]
VAQVVWTQRAMADVYAIVGHISEQSRPLAAQRLAKRLFDTGASLATYPERGRVSTQGRREIVAISPYVLRYRIVGDRVVI
GSVRHGARRPL

Nucleotide

• Length: 276 bp

>T80721 NZ_CP023313:3437316-3437591 [Caulobacter vibrioides]
GTGGCGCAAGTAGTCTGGACCCAACGAGCGATGGCCGATGTTTACGCCATCGTCGGCCATATCTCCGAGCAGTCGCGTCC
TCTCGCGGCCCAGCGCCTGGCCAAGAGGTTGTTCGACACCGGCGCTAGCCTGGCGACCTATCCCGAACGCGGGCGCGTGA
GCACTCAAGGACGGCGAGAGATCGTCGCGATTTCGCCCTACGTTCTGCGCTACCGCATTGTCGGCGACCGTGTCGTCATT
GGCAGCGTACGCCATGGGGCGCGTCGACCTCTCTAG

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6606.17 Da
• Isoelectric Point: 3.9689

>AT80721 WP_012640671.1 NZ_CP023313:3437149-3437328 [Caulobacter vibrioides]
MAEPDPDIFDEDDEAILAADAEADADFEAGRTVPHERVGEWLKTLGTPHQTPPPYSWRK

Nucleotide

• Length: 180 bp

>AT80721 NZ_CP023313:3437149-3437328 [Caulobacter vibrioides]
ATGGCCGAGCCTGACCCCGACATCTTCGACGAGGACGATGAAGCGATCCTGGCGGCTGACGCCGAGGCTGACGCCGACTT
CGAAGCCGGTAGAACTGTTCCGCACGAGCGTGTGGGCGAGTGGCTCAAGACGTTGGGCACGCCGCACCAGACACCGCCAC
CATATTCGTGGCGCAAGTAG

Structures

Antitoxin

• AlphaFold DB: P0CW75