Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3054599..3056262 Replicon chromosome
Accession NZ_CP023313
Organism Caulobacter vibrioides strain CB2

Toxin (Protein)


Gene name HipA3 Uniprot ID -
Locus tag CA608_RS14890 Protein ID WP_096033974.1
Coordinates 3054599..3055906 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name HipB3 Uniprot ID -
Locus tag CA608_RS14895 Protein ID WP_010920612.1
Coordinates 3055903..3056262 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA608_RS14860 3049785..3051155 - 1371 WP_096033971.1 hypothetical protein -
CA608_RS14865 3051316..3052707 - 1392 WP_096034807.1 sensor histidine kinase -
CA608_RS14870 3052749..3053426 - 678 WP_010920607.1 response regulator transcription factor -
CA608_RS14875 3053442..3053759 - 318 WP_010920608.1 PepSY domain-containing protein -
CA608_RS14880 3053888..3054397 - 510 WP_096033972.1 hypothetical protein -
CA608_RS14890 3054599..3055906 - 1308 WP_096033974.1 type II toxin-antitoxin system HipA family toxin Toxin
CA608_RS14895 3055903..3056262 - 360 WP_010920612.1 helix-turn-helix domain-containing protein Antitoxin
CA608_RS14900 3056425..3057372 - 948 WP_096033975.1 J domain-containing protein -
CA608_RS14905 3057461..3061171 - 3711 WP_205685752.1 glycoside hydrolase TIM-barrel-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(170-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-67)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 47789.19 Da        Isoelectric Point: 7.0752

>T80720 WP_096033974.1 NZ_CP023313:c3055906-3054599 [Caulobacter vibrioides]
MTTVAEVRLWGSRIGAVSLEDGAQTAVFAYEPGFIASGIQPAPLMMPLKAGVFSFPDLPPRSFHGLPGMLADALPDKYGH
VLIDAWLATQGRSPESFNAVERLCYTGRRGMGALEFSPMAGPRRRVSSKIDIDALVTLASEVLTHRHDLRASFADADKAD
ALRDILSVGTSAGGARAKAVIAWNPATNEVRSGQVEAGAGFGYWLLKFDGVSGNRDKELADPKGYGAVEHAYGQMAAAAG
IDVAESRLLEEGGRRHFMSKRFDRLDGGGKLHMQSLAAIAHLDFNDPVANSYEQALFTMRRMGLPMAQLEEQFRRMVFNV
LARNQDDHVKNIAFLMDRAGRWSLSPAFDITWSYNPDGEWTSRHQMSINGKRDGFDFADLEACAKTASISRGHVGRIFEE
VRAAVMRWPTFADAAGVDERWRDQIGATLRLELRR

Download         Length: 1308 bp

>T80720 NZ_CP023313:c3055906-3054599 [Caulobacter vibrioides]
ATGACCACCGTCGCCGAGGTTCGCCTGTGGGGCAGCCGGATCGGCGCGGTGTCGCTGGAAGACGGCGCCCAGACGGCGGT
CTTCGCCTATGAGCCGGGCTTTATCGCCAGCGGAATCCAGCCCGCCCCGCTGATGATGCCGCTGAAGGCCGGCGTGTTCA
GCTTTCCCGATCTGCCGCCGCGCAGCTTCCATGGCCTGCCCGGCATGCTGGCCGACGCCCTGCCGGACAAGTACGGCCAT
GTGCTGATCGACGCCTGGCTGGCCACGCAAGGTCGCAGCCCCGAGAGCTTCAACGCCGTCGAGCGCCTTTGCTACACCGG
CCGCCGGGGCATGGGGGCGCTGGAGTTCTCGCCGATGGCGGGGCCGCGTCGGCGGGTCTCCAGCAAGATCGACATCGACG
CCCTGGTGACCCTGGCTTCGGAGGTGCTGACCCATCGCCACGACCTGCGCGCCTCGTTCGCCGATGCGGACAAGGCCGAC
GCCCTGCGCGACATCTTGAGCGTCGGCACCTCGGCGGGCGGGGCGCGGGCCAAGGCGGTGATCGCCTGGAACCCGGCAAC
CAACGAAGTGCGCTCCGGTCAGGTCGAGGCGGGCGCGGGTTTCGGCTACTGGCTGCTGAAGTTCGACGGCGTCTCCGGCA
ACCGGGACAAGGAACTGGCCGACCCCAAGGGCTATGGCGCGGTCGAGCACGCCTATGGACAGATGGCGGCGGCGGCGGGA
ATCGACGTCGCCGAGAGTCGCTTGCTGGAGGAGGGCGGTCGTCGCCACTTCATGAGCAAGCGCTTCGACCGGCTGGACGG
CGGCGGCAAGCTGCACATGCAGTCGCTGGCCGCCATCGCCCATCTGGATTTCAACGATCCCGTCGCCAATTCCTATGAAC
AGGCCCTGTTCACGATGCGGCGGATGGGCCTGCCGATGGCGCAGTTGGAAGAGCAGTTCCGGCGCATGGTCTTCAACGTG
TTGGCGCGAAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGGACCGCGCAGGACGCTGGAGCCTGTCACCGGC
CTTCGACATCACCTGGAGCTACAATCCGGACGGCGAATGGACCTCGCGCCACCAGATGTCGATCAACGGCAAGCGGGACG
GGTTCGACTTCGCCGATCTGGAGGCCTGCGCGAAAACCGCCTCGATCAGTCGCGGTCATGTCGGCCGGATCTTTGAAGAG
GTGCGGGCGGCCGTGATGCGCTGGCCGACCTTCGCCGACGCGGCCGGCGTGGACGAGCGCTGGCGGGATCAGATCGGCGC
GACGCTGCGGCTGGAGCTCAGGCGGTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13019.91 Da        Isoelectric Point: 10.1741

>AT80720 WP_010920612.1 NZ_CP023313:c3056262-3055903 [Caulobacter vibrioides]
MKFESLLSDEAVLAEMGQRLVAARLERRLTQAQLAQAAGVSKRTVERLEDGASAQLTNLVRCLRALDRLEGLERLLPETP
ANPLDLLKQAKTGRSRVRNARASGVAETGGAPWVWGDEK

Download         Length: 360 bp

>AT80720 NZ_CP023313:c3056262-3055903 [Caulobacter vibrioides]
ATGAAATTTGAATCTCTCCTGTCCGATGAGGCGGTGTTGGCCGAGATGGGTCAGCGTCTGGTGGCGGCGCGGCTGGAGCG
GCGGCTGACCCAGGCTCAGCTGGCGCAGGCCGCCGGCGTGTCCAAGCGCACCGTCGAGCGTCTGGAAGACGGCGCCTCGG
CCCAGCTGACCAATCTGGTGCGCTGCCTGCGGGCCCTGGACCGGCTGGAGGGGCTGGAGCGCCTGCTGCCCGAGACGCCC
GCCAATCCGCTGGACCTGCTGAAACAGGCCAAGACCGGCCGCTCAAGAGTGCGCAACGCCCGCGCGTCCGGCGTCGCCGA
GACCGGCGGCGCGCCTTGGGTGTGGGGCGATGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References