Detailed information of TA system TA080717

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagD-vapB/VapC-VagC
• Location: 360023..360699
• Replicon: chromosome
• Accession: NZ_CP023313
• Organism: Caulobacter vibrioides strain CB2

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: CA608_RS01735
• Protein ID: WP_125469911.1
• Coordinates: 360292..360699 (+)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: CA608_RS01730
• Protein ID: WP_096032307.1
• Coordinates: 360023..360295 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA608_RS01715	355305..358268	+	2964	WP_010918228.1	2-oxoglutarate dehydrogenase E1 component	-
CA608_RS01720	358328..359551	+	1224	WP_096032305.1	2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase	-
CA608_RS01725	359629..359976	+	348	WP_096032306.1	DUF3088 family protein	-
CA608_RS01730	360023..360295	+	273	WP_096032307.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CA608_RS01735	360292..360699	+	408	WP_125469911.1	type II toxin-antitoxin system VapC family toxin	Toxin
CA608_RS01740	361039..362439	+	1401	WP_096032308.1	dihydrolipoyl dehydrogenase	-
CA608_RS20625	362529..362708	+	180	WP_205685762.1	hypothetical protein	-
CA608_RS01745	362838..364841	-	2004	WP_096032309.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-127)

Antitoxin

• SpoVT-AbrB domain (14-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15054.16 Da
• Isoelectric Point: 6.4011

>T80717 WP_125469911.1 NZ_CP023313:360292-360699 [Caulobacter vibrioides]
VTLALDTNVIIDLIRGRRPGVRARYDAAILGGRPLVTSLIAYYELQFGAFASRDRERQWTATKAVLEEILVEPLDQSDVI
TAASIRDELRRTGTPIGPYDLLIAGQARNRGWTLATSNIKEFRRVGALELEDWSA

Nucleotide

• Length: 408 bp

>T80717 NZ_CP023313:360292-360699 [Caulobacter vibrioides]
GTGACGCTGGCGCTCGACACTAACGTTATTATCGATCTCATTCGCGGCCGCCGACCGGGTGTCCGTGCGCGCTACGATGC
GGCGATCCTCGGGGGGCGGCCGCTGGTGACGTCCTTGATCGCTTACTACGAGCTTCAATTCGGAGCTTTTGCCAGCCGCG
ACCGCGAGCGGCAATGGACCGCCACGAAAGCGGTTCTGGAAGAGATTCTAGTTGAACCCTTGGACCAGAGCGATGTGATC
ACCGCCGCCTCTATCCGAGATGAGTTGCGCAGAACAGGGACCCCTATTGGCCCATATGATCTGCTCATTGCGGGGCAGGC
CCGCAATCGCGGTTGGACGCTCGCCACCTCGAATATCAAGGAGTTCCGCCGCGTGGGGGCGCTCGAACTGGAAGACTGGT
CAGCCTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 9838.25 Da
• Isoelectric Point: 5.1532

>AT80717 WP_096032307.1 NZ_CP023313:360023-360295 [Caulobacter vibrioides]
MGKLDTPPARAKLFMHGGSQAVRLPKAFRFEGAEVMVTREGDKVILEPVGPKPARTAEDLAAMWARIDALGGADFPDREQ
PGMQERDFGE

Nucleotide

• Length: 273 bp

>AT80717 NZ_CP023313:360023-360295 [Caulobacter vibrioides]
ATGGGAAAGCTCGATACTCCGCCGGCTCGAGCCAAGCTCTTCATGCACGGCGGCAGTCAGGCGGTTCGCCTGCCAAAGGC
CTTCCGTTTCGAGGGGGCGGAGGTCATGGTCACGCGTGAAGGCGACAAGGTTATCCTTGAGCCCGTCGGACCAAAGCCCG
CGCGCACGGCTGAAGATCTGGCCGCCATGTGGGCGCGCATCGACGCCTTAGGGGGCGCTGACTTTCCTGATCGCGAACAG
CCCGGCATGCAGGAGCGGGACTTCGGCGAGTGA