Detailed information of TA system TA080716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 753375..753915
• Replicon: chromosome
• Accession: NZ_CP023311
• Organism: Vibrio anguillarum strain VIB12 isolate Sea bass

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: CMV05_RS19565
• Protein ID: WP_096037051.1
• Coordinates: 753375..753665 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A233HQC6
• Locus tag: CMV05_RS19570
• Protein ID: WP_017045808.1
• Coordinates: 753673..753915 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CMV05_RS19525	749055..749236	-	182	Protein_733	DUF645 family protein	-
CMV05_RS19530	749421..749555	-	135	WP_080729748.1	DUF3265 domain-containing protein	-
CMV05_RS19535	749539..749736	-	198	WP_096037049.1	hypothetical protein	-
CMV05_RS19545	750795..750920	+	126	WP_096037050.1	DUF3265 domain-containing protein	-
CMV05_RS19550	751121..751441	+	321	WP_096036147.1	IS66 family insertion sequence hypothetical protein	-
CMV05_RS19555	751438..751791	+	354	WP_061778452.1	IS66 family insertion sequence element accessory protein TnpB	-
CMV05_RS19560	751851..753383	+	1533	WP_076611502.1	IS66-like element ISVa12 family transposase	-
CMV05_RS19565	753375..753665	-	291	WP_096037051.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CMV05_RS19570	753673..753915	-	243	WP_017045808.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CMV05_RS19575	754026..755264	+	1239	WP_086558351.1	IS256-like element ISVa19 family transposase	-
CMV05_RS19580	755542..756108	+	567	WP_096037052.1	hypothetical protein	-
CMV05_RS19585	756134..757102	-	969	WP_096037023.1	IS30-like element ISVa6 family transposase	-
CMV05_RS19590	757133..757309	+	177	WP_172859068.1	DUF3265 domain-containing protein	-
CMV05_RS19595	757346..758038	+	693	WP_096037053.1	hypothetical protein	-
CMV05_RS19600	758231..758551	+	321	Protein_748	DUF4277 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	682266..761421	79155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-78)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-47)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11116.91 Da
• Isoelectric Point: 9.7892

>T80716 WP_096037051.1 NZ_CP023311:c753665-753375 [Vibrio anguillarum]
MYKNKYKLSKLAQAHLHKIKNYTVTNFSEMQWNAYKDTLLTGFQMLADNPAVGRSCNDLYQNGFYFPIGKHTAYFAKEDS
FICMRPIIPRGVLISV

Nucleotide

• Length: 291 bp

>T80716 NZ_CP023311:c753665-753375 [Vibrio anguillarum]
ATGTACAAGAATAAATATAAACTAAGTAAATTAGCACAGGCTCATTTACATAAAATCAAAAATTATACCGTTACAAACTT
TTCCGAGATGCAGTGGAACGCATACAAAGATACTCTTCTTACTGGGTTTCAGATGCTCGCTGACAACCCAGCGGTAGGCA
GAAGCTGCAACGATTTATATCAAAATGGTTTTTACTTCCCTATAGGCAAGCATACGGCTTACTTTGCCAAGGAAGACAGC
TTTATTTGTATGCGCCCCATAATCCCACGGGGCGTTTTAATTTCAGTGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9036.28 Da
• Isoelectric Point: 4.7672

>AT80716 WP_017045808.1 NZ_CP023311:c753915-753673 [Vibrio anguillarum]
MYTLTANDAKRNFGELLLNAQREPVKISKNNKDAVVVMSIRDYEELEVMKADYIKHCFESAKADLAQGNIVDGENFLNAL

Nucleotide

• Length: 243 bp

>AT80716 NZ_CP023311:c753915-753673 [Vibrio anguillarum]
ATGTACACATTAACAGCAAATGATGCCAAACGTAATTTCGGTGAACTGCTTCTAAACGCTCAACGTGAGCCAGTTAAAAT
TAGTAAAAACAATAAAGATGCCGTTGTTGTGATGTCGATTAGAGACTATGAAGAACTTGAAGTCATGAAAGCCGATTACA
TAAAACATTGTTTTGAGTCCGCAAAAGCAGACTTAGCCCAAGGCAATATAGTTGACGGTGAAAATTTCCTAAACGCGTTG
TAA

Structures

Antitoxin

• AlphaFold DB: A0A233HQC6