Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 700239..701005 | Replicon | chromosome |
| Accession | NZ_CP023311 | ||
| Organism | Vibrio anguillarum strain VIB12 isolate Sea bass | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A290PTK1 |
| Locus tag | CMV05_RS19185 | Protein ID | WP_017045788.1 |
| Coordinates | 700508..701005 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A290Q6J3 |
| Locus tag | CMV05_RS19180 | Protein ID | WP_019283269.1 |
| Coordinates | 700239..700511 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| CMV05_RS19140 | 696101..696454 | - | 354 | WP_019283195.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CMV05_RS19145 | 696451..696771 | - | 321 | WP_096036125.1 | IS66 family insertion sequence hypothetical protein | - |
| CMV05_RS23720 | 696851..697012 | + | 162 | Protein_668 | IS30 family transposase | - |
| CMV05_RS19150 | 697362..697763 | - | 402 | Protein_669 | hypothetical protein | - |
| CMV05_RS19155 | 697934..698338 | - | 405 | WP_017039704.1 | DUF1801 domain-containing protein | - |
| CMV05_RS19160 | 698476..699012 | - | 537 | WP_095470047.1 | nucleotidyltransferase family protein | - |
| CMV05_RS19175 | 700038..700199 | - | 162 | WP_096037229.1 | DUF3265 domain-containing protein | - |
| CMV05_RS19180 | 700239..700511 | + | 273 | WP_019283269.1 | DUF1778 domain-containing protein | Antitoxin |
| CMV05_RS19185 | 700508..701005 | + | 498 | WP_017045788.1 | GNAT family N-acetyltransferase | Toxin |
| CMV05_RS19190 | 701246..702778 | - | 1533 | WP_096036126.1 | IS66-like element ISVa11 family transposase | - |
| CMV05_RS19195 | 702838..703191 | - | 354 | WP_019283195.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| CMV05_RS19200 | 703188..703283 | - | 96 | Protein_677 | IS66 family insertion sequence element accessory protein TnpB | - |
| CMV05_RS19210 | 704828..705079 | - | 252 | WP_096037036.1 | IS66 family insertion sequence hypothetical protein | - |
| CMV05_RS19215 | 705351..705464 | + | 114 | WP_096037037.1 | DUF3265 domain-containing protein | - |
| CMV05_RS19220 | 705490..705915 | + | 426 | WP_045571622.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 682266..761421 | 79155 | |
| - | inside | Integron | - | - | 697038..702778 | 5740 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18524.30 Da Isoelectric Point: 9.2813
>T80714 WP_017045788.1 NZ_CP023311:700508-701005 [Vibrio anguillarum]
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKTLPDKLQKKHQ
SSTSGGLIARLAIDDSYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG
MMKTVLLDKDKHDRNRFNCGIDALNNYLKVMASQQAKKDNTRTFVLEDENNTSLIIGFYTLTMTPIDLKTLPDKLQKKHQ
SSTSGGLIARLAIDDSYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFKAFQDAENKLFITISDI
RASLG
Download Length: 498 bp
>T80714 NZ_CP023311:700508-701005 [Vibrio anguillarum]
ATGATGAAAACGGTATTACTCGATAAAGATAAACACGACAGAAACCGATTCAACTGCGGAATTGATGCGCTTAATAACTA
TTTGAAAGTCATGGCAAGTCAGCAAGCTAAAAAAGATAATACCCGAACATTTGTTTTAGAGGATGAAAATAACACCTCAC
TTATCATCGGTTTTTACACTTTAACAATGACACCCATTGACCTAAAAACATTGCCTGATAAGTTACAGAAAAAGCATCAG
TCATCAACTTCTGGCGGACTCATTGCTCGCTTAGCTATCGATGATAGCTATAAAGGTAAAGGATTTGGCGAGTGGTTACT
TATCGATGCTCTACGAAAACTACTAGCAGCTAGTGATAGCGTGGCATTTCCCGTCGTTATTGTTGACGCAAAAGATGGCG
CCAAACATTTCTATGAGCGCTATGGTTTTAAAGCGTTTCAAGATGCAGAAAATAAGCTATTTATCACCATTTCAGATATT
AGGGCAAGTTTAGGCTAG
ATGATGAAAACGGTATTACTCGATAAAGATAAACACGACAGAAACCGATTCAACTGCGGAATTGATGCGCTTAATAACTA
TTTGAAAGTCATGGCAAGTCAGCAAGCTAAAAAAGATAATACCCGAACATTTGTTTTAGAGGATGAAAATAACACCTCAC
TTATCATCGGTTTTTACACTTTAACAATGACACCCATTGACCTAAAAACATTGCCTGATAAGTTACAGAAAAAGCATCAG
TCATCAACTTCTGGCGGACTCATTGCTCGCTTAGCTATCGATGATAGCTATAAAGGTAAAGGATTTGGCGAGTGGTTACT
TATCGATGCTCTACGAAAACTACTAGCAGCTAGTGATAGCGTGGCATTTCCCGTCGTTATTGTTGACGCAAAAGATGGCG
CCAAACATTTCTATGAGCGCTATGGTTTTAAAGCGTTTCAAGATGCAGAAAATAAGCTATTTATCACCATTTCAGATATT
AGGGCAAGTTTAGGCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9917.47 Da Isoelectric Point: 9.8130
>AT80714 WP_019283269.1 NZ_CP023311:700239-700511 [Vibrio anguillarum]
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQTDAILLMEALDKPTTLNQKLKT
AAERYETRTQ
MATTLPRITARVDVDTQNLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQTLKLSQTDAILLMEALDKPTTLNQKLKT
AAERYETRTQ
Download Length: 273 bp
>AT80714 NZ_CP023311:700239-700511 [Vibrio anguillarum]
ATGGCTACCACTTTACCTCGTATCACTGCGAGAGTTGATGTCGATACACAAAACTTATTAACCAAAGCGGCTGCTCTCGC
TGGCATGTCTAGTATTAACTCATTTGTACTCAATGCTGCAATCGAAAAAGCAAAGCAAGTGATTGAACGCGAACAAACAC
TAAAATTAAGCCAAACAGACGCCATTTTACTTATGGAAGCTCTCGATAAACCAACAACATTAAATCAAAAGCTTAAAACT
GCCGCCGAACGCTATGAGACCAGAACCCAATGA
ATGGCTACCACTTTACCTCGTATCACTGCGAGAGTTGATGTCGATACACAAAACTTATTAACCAAAGCGGCTGCTCTCGC
TGGCATGTCTAGTATTAACTCATTTGTACTCAATGCTGCAATCGAAAAAGCAAAGCAAGTGATTGAACGCGAACAAACAC
TAAAATTAAGCCAAACAGACGCCATTTTACTTATGGAAGCTCTCGATAAACCAACAACATTAAATCAAAAGCTTAAAACT
GCCGCCGAACGCTATGAGACCAGAACCCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A290PTK1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A290Q6J3 |