Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 28653..29320 Replicon chromosome
Accession NZ_CP023285
Organism Xanthomonas citri pv. citri strain 03-1638-1-1

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag CLM98_RS00135 Protein ID WP_005916679.1
Coordinates 28904..29320 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag CLM98_RS00130 Protein ID WP_005916676.1
Coordinates 28653..28907 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM98_RS25100 24775..24994 + 220 Protein_18 RNA 2'-phosphotransferase -
CLM98_RS00110 25151..26416 + 1266 WP_015463799.1 cardiolipin synthase B -
CLM98_RS00115 26442..26969 - 528 WP_005916668.1 hypothetical protein -
CLM98_RS00120 27208..27414 + 207 WP_003489327.1 hypothetical protein -
CLM98_RS00125 27401..28507 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
CLM98_RS00130 28653..28907 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
CLM98_RS00135 28904..29320 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
CLM98_RS25105 29442..29654 - 213 WP_015472900.1 hypothetical protein -
CLM98_RS25110 29773..29985 - 213 WP_015472901.1 hypothetical protein -
CLM98_RS00140 30242..31861 + 1620 WP_015463800.1 hypothetical protein -
CLM98_RS00145 31965..32363 - 399 WP_004429277.1 DUF2384 domain-containing protein -
CLM98_RS00150 32679..33110 + 432 WP_005922907.1 hypothetical protein -
CLM98_RS00155 33139..33465 - 327 Protein_30 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T80704 WP_005916679.1 NZ_CP023285:28904-29320 [Xanthomonas citri pv. citri]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T80704 NZ_CP023285:28904-29320 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT80704 WP_005916676.1 NZ_CP023285:28653-28907 [Xanthomonas citri pv. citri]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT80704 NZ_CP023285:28653-28907 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References