Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3219356..3221095 Replicon chromosome
Accession NZ_CP023284
Organism Variovorax boronicumulans strain J1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag CKY39_RS14750 Protein ID WP_095744976.1
Coordinates 3219356..3220225 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A554S243
Locus tag CKY39_RS14755 Protein ID WP_070060330.1
Coordinates 3220262..3221095 (+) Length 278 a.a.

Genomic Context

CKY39_RS14725CKY39_RS14730CKY39_RS14735CKY39_RS14740CKY39_RS14745CKY39_RS14750CKY39_RS14755CKY39_RS14760CKY39_RS14765CKY39_RS14770CKY39_RS14775
Location: 3214455..3215423 (969 bp)
Type: Others
Protein ID: WP_157755232.1
Location: 3215478..3216737 (1260 bp)
Type: Others
Protein ID: WP_095744974.1
Location: 3216929..3217912 (984 bp)
Type: Others
Protein ID: WP_062474573.1
Location: 3217990..3218748 (759 bp)
Type: Others
Protein ID: WP_185993640.1
Location: 3218792..3219328 (537 bp)
Type: Others
Protein ID: WP_062474577.1
Location: 3219356..3220225 (870 bp)
Type: Toxin
Protein ID: WP_095744976.1
Location: 3220262..3221095 (834 bp)
Type: Antitoxin
Protein ID: WP_070060330.1
Location: 3221116..3221955 (840 bp)
Type: Others
Protein ID: WP_095744977.1
Location: 3221948..3223645 (1698 bp)
Type: Others
Protein ID: WP_062474586.1
Location: 3223666..3224466 (801 bp)
Type: Others
Protein ID: WP_062474588.1
Location: 3224475..3225950 (1476 bp)
Type: Others
Protein ID: WP_095744978.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
CKY39_RS147253214455..3215423+969WP_157755232.12-dehydropantoate 2-reductase-
CKY39_RS147303215478..3216737+1260WP_095744974.1D-amino acid dehydrogenase-
CKY39_RS147353216929..3217912+984WP_062474573.1tripartite tricarboxylate transporter substrate binding protein-
CKY39_RS147403217990..3218748+759WP_185993640.1SDR family oxidoreductase-
CKY39_RS147453218792..3219328+537WP_062474577.1cupin domain-containing protein-
CKY39_RS147503219356..3220225+870WP_095744976.1alpha/beta hydrolaseToxin
CKY39_RS147553220262..3221095+834WP_070060330.1IclR family transcriptional regulatorAntitoxin
CKY39_RS147603221116..3221955+840WP_095744977.1SDR family oxidoreductase-
CKY39_RS147653221948..3223645+1698WP_062474586.1thiamine pyrophosphate-binding protein-
CKY39_RS147703223666..3224466+801WP_062474588.1aspartate dehydrogenase-
CKY39_RS147753224475..3225950+1476WP_095744978.1aldehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(47-281)

Antitoxin

Transcription regulator IclR, C-terminal

(139-258)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 29898.21 Da        Isoelectric Point: 6.0184

>T80703 WP_095744976.1 NZ_CP023284:3219356-3220225 [Variovorax boronicumulans]
MSTVDISAQTLPASELARLDARFPARDVAVGGGAVVSVRECGQGPVIVCLHGIGSGAASWLDTAALLAPQACLIAWDAPG
YGRSTPLASAAPTAADYAARLEEMLDALSIRSCVLVGHSLGAIVAASAARSESSASERIRRLVLVSPAIGYGAAGRIDAR
AKVRAERLATLDDLGIAGMAAKRAGRLVSDGASEHARQWVRWNMARLNDHGYRQAVELLCNADLLADLPPPMPVRVACGA
LDVVTPPTACEEVARRCGVPLELVDDAGHAGYVEQPQAVAALLRESLAG

Download         Length: 870 bp

>T80703 NZ_CP023284:3219356-3220225 [Variovorax boronicumulans]
ATGAGCACCGTCGACATCTCCGCGCAGACCCTGCCGGCTTCCGAGCTGGCGCGACTCGACGCGCGCTTTCCGGCCCGCGA
CGTCGCGGTGGGCGGCGGCGCGGTGGTGTCGGTGCGCGAATGCGGGCAGGGCCCGGTCATCGTGTGCCTGCACGGCATCG
GCTCGGGCGCGGCCTCGTGGCTCGACACCGCGGCGCTGCTGGCGCCGCAGGCCTGCCTCATCGCCTGGGATGCACCGGGC
TACGGCCGCTCGACGCCGCTGGCCTCGGCCGCGCCGACCGCCGCGGACTACGCCGCACGCCTTGAAGAAATGCTCGACGC
GCTGTCGATCCGCTCCTGCGTGCTCGTCGGCCATTCGCTGGGCGCCATCGTGGCCGCGTCGGCTGCGCGCAGCGAGTCGA
GCGCCAGTGAGCGCATCCGCCGCCTCGTGCTCGTGAGCCCCGCCATCGGCTACGGCGCCGCCGGGCGCATCGACGCCCGC
GCCAAGGTGCGCGCCGAACGCCTGGCCACGCTCGACGACCTCGGCATTGCCGGCATGGCCGCCAAGCGCGCGGGCCGGCT
CGTGTCCGACGGTGCCAGCGAACACGCCCGCCAGTGGGTGCGTTGGAACATGGCGCGTCTGAACGACCACGGCTACCGCC
AGGCCGTCGAGCTGCTGTGCAACGCCGACCTGCTGGCCGACCTGCCGCCGCCGATGCCCGTGCGCGTGGCCTGCGGCGCG
CTCGACGTCGTCACGCCGCCCACCGCCTGCGAAGAAGTCGCGCGCCGCTGCGGCGTGCCCCTCGAATTGGTGGACGATGC
GGGTCACGCCGGCTATGTGGAACAACCGCAGGCCGTCGCCGCCTTGCTGCGCGAATCGCTCGCCGGCTGA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30605.96 Da        Isoelectric Point: 5.7705

>AT80703 WP_070060330.1 NZ_CP023284:3220262-3221095 [Variovorax boronicumulans]
MATDNEVMEEGADRYNVPALERGLRVLCEFSRESRTLSAPELARRFDLPRSTVFRLLTTLENMGFLERAEGGRDYRLGLA
VLRLGFEYLASLELTQLGTPLLNRLCDELRTPCNLVVRDGRSIVYVAKVAPATPFASSVTVGTRLPAHATVLGRILLEDL
TLPQLRALYPEDKLETFSPSTPKTVNELFDMVQADRQRGYVLGEGFFESNISTIAAPVRDHSGHIVAALGATITSGHIDE
NRMDEMVQRVRGTADEISGLLNYSPARTSKVVPLRSA

Download         Length: 834 bp

>AT80703 NZ_CP023284:3220262-3221095 [Variovorax boronicumulans]
ATGGCCACCGACAACGAAGTGATGGAAGAGGGCGCGGACCGCTACAACGTGCCCGCGCTGGAGCGCGGCCTGCGCGTGCT
GTGCGAGTTCAGCCGCGAGAGCCGCACGCTGTCCGCGCCCGAGCTGGCGCGCCGCTTCGACCTGCCGCGCTCGACCGTCT
TCCGCCTGCTCACCACGCTGGAGAACATGGGTTTTCTCGAGCGCGCCGAGGGCGGACGCGACTACCGCCTGGGCCTGGCC
GTGCTGCGCCTGGGCTTCGAATACCTGGCCTCGCTGGAACTCACGCAACTGGGCACGCCGCTGCTCAACCGCCTGTGCGA
CGAGCTGCGCACGCCCTGCAACCTGGTGGTGCGCGACGGCCGCTCGATCGTCTACGTCGCCAAGGTGGCACCGGCCACGC
CCTTCGCCAGCTCGGTCACGGTGGGTACGCGCCTGCCGGCCCACGCCACGGTGCTGGGCCGCATCCTGCTGGAAGACCTC
ACGCTGCCGCAGCTGCGCGCGCTGTACCCCGAAGACAAGCTCGAGACCTTCTCGCCGAGCACGCCCAAGACCGTGAACGA
GCTCTTCGACATGGTGCAGGCCGACCGCCAGCGCGGCTATGTGCTGGGCGAGGGCTTCTTCGAATCGAACATCTCGACCA
TCGCCGCACCGGTGCGCGACCACAGCGGCCACATCGTGGCGGCACTGGGCGCCACCATCACCTCGGGCCACATCGACGAG
AACCGCATGGACGAGATGGTGCAGCGCGTGCGCGGCACCGCCGACGAGATCTCGGGCCTGCTCAATTACTCGCCCGCGCG
CACCAGCAAGGTGGTGCCGCTGCGCAGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A554S243

References