Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4752919..4753525 Replicon chromosome
Accession NZ_CP023278
Organism Nostoc sp. CENA543

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CLI64_RS19790 Protein ID WP_103138808.1
Coordinates 4753229..4753525 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CLI64_RS19785 Protein ID WP_103138807.1
Coordinates 4752919..4753239 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLI64_RS19765 4749226..4749579 - 354 WP_103138803.1 DUF5615 family PIN-like protein -
CLI64_RS19770 4749576..4749908 - 333 WP_103138804.1 DUF433 domain-containing protein -
CLI64_RS19775 4750217..4750987 - 771 WP_103138805.1 Ycf66 family protein -
CLI64_RS19780 4751328..4752758 + 1431 WP_103138806.1 NADP-dependent phosphogluconate dehydrogenase -
CLI64_RS19785 4752919..4753239 - 321 WP_103138807.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CLI64_RS19790 4753229..4753525 - 297 WP_103138808.1 type II toxin-antitoxin system HicA family toxin Toxin
CLI64_RS19795 4753644..4754774 - 1131 WP_103138809.1 serine/threonine protein kinase -
CLI64_RS19800 4754876..4755130 - 255 WP_103138810.1 type II toxin-antitoxin system RelE/ParE family toxin -
CLI64_RS19805 4755117..4755275 - 159 Protein_3877 prevent-host-death protein -
CLI64_RS19810 4755682..4756713 + 1032 WP_103138811.1 hypothetical protein -
CLI64_RS19815 4756794..4757360 - 567 WP_103138812.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-79)

Antitoxin

Uncharacterised protein family HicB

(51-101)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10859.26 Da        Isoelectric Point: 5.7587

>T80702 WP_103138808.1 NZ_CP023278:c4753525-4753229 [Nostoc sp. CENA543]
MEINSKHKKTLDDIFETPIKSNISWSDIESMLIALGAEVSEGRGSRVRIVLNGVKATFHRPNPEKETDKGAVKSMRRFLT
ESGIKEVADTGETGNDEI

Download         Length: 297 bp

>T80702 NZ_CP023278:c4753525-4753229 [Nostoc sp. CENA543]
ATGGAAATCAACAGTAAACATAAAAAAACACTAGATGACATCTTTGAAACCCCTATTAAATCCAATATCTCTTGGAGTGA
TATTGAGTCTATGCTGATTGCGCTTGGTGCAGAAGTGTCAGAAGGAAGGGGGTCAAGAGTAAGAATAGTTCTTAATGGTG
TAAAGGCTACTTTTCACAGACCAAATCCAGAAAAAGAAACTGATAAAGGTGCTGTTAAATCTATGCGTCGCTTCTTAACG
GAGTCTGGTATTAAAGAAGTTGCGGATACAGGAGAAACTGGTAACGATGAAATATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12333.00 Da        Isoelectric Point: 4.8175

>AT80702 WP_103138807.1 NZ_CP023278:c4753239-4752919 [Nostoc sp. CENA543]
MKYKGYEAVVEFDDEAEIFHGEVINLRDVITFQSDNAKELKQAFHDSVDDYLEFCKERGEEPEKPFSGKLMLRINPELHK
TIAIKAKKEGQSINSWIEKCLFIYAS

Download         Length: 321 bp

>AT80702 NZ_CP023278:c4753239-4752919 [Nostoc sp. CENA543]
ATGAAATATAAAGGATATGAAGCCGTTGTTGAGTTTGATGATGAGGCTGAAATTTTTCATGGTGAAGTCATCAATCTGCG
TGATGTGATTACATTTCAGAGTGATAATGCAAAAGAACTAAAGCAAGCTTTTCATGACTCAGTTGATGATTATTTAGAGT
TTTGTAAAGAACGTGGTGAAGAACCTGAAAAACCATTTTCAGGTAAACTGATGCTGAGAATTAACCCTGAGCTACATAAA
ACAATTGCTATCAAAGCCAAGAAAGAAGGTCAAAGTATTAATTCTTGGATAGAAAAATGCTTGTTCATTTATGCTAGTTA
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References