Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 1025922..1026493 Replicon chromosome
Accession NZ_CP023278
Organism Nostoc sp. CENA543

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CLI64_RS04240 Protein ID WP_103136053.1
Coordinates 1025922..1026263 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CLI64_RS04245 Protein ID WP_103140586.1
Coordinates 1026260..1026493 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLI64_RS04205 1020955..1021596 + 642 WP_103136048.1 fimbrial protein -
CLI64_RS04210 1021726..1021965 + 240 WP_103136049.1 hypothetical protein -
CLI64_RS04215 1022033..1022902 - 870 WP_103136050.1 PD-(D/E)XK nuclease family protein -
CLI64_RS04220 1023010..1024434 + 1425 WP_103136051.1 phosphoglucomutase/phosphomannomutase family protein -
CLI64_RS04225 1024504..1024776 + 273 WP_103140585.1 DUF1049 domain-containing protein -
CLI64_RS04230 1024779..1025025 + 247 Protein_832 BrnA antitoxin family protein -
CLI64_RS04235 1025060..1025809 + 750 WP_103136052.1 hypothetical protein -
CLI64_RS04240 1025922..1026263 - 342 WP_103136053.1 DUF5615 family PIN-like protein Toxin
CLI64_RS04245 1026260..1026493 - 234 WP_103140586.1 DUF433 domain-containing protein Antitoxin
CLI64_RS04250 1026724..1027386 + 663 WP_103136054.1 Uma2 family endonuclease -
CLI64_RS04255 1027389..1027619 + 231 WP_103136055.1 DUF433 domain-containing protein -
CLI64_RS04260 1027616..1027894 + 279 WP_103136056.1 DUF5615 family PIN-like protein -
CLI64_RS04265 1027971..1028651 - 681 WP_103136057.1 hypothetical protein -
CLI64_RS04270 1028896..1029615 - 720 WP_103136058.1 Uma2 family endonuclease -
CLI64_RS04275 1029787..1030104 + 318 WP_103136059.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-78)

Antitoxin

Protein of unknown function DUF433

(11-66)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12621.58 Da        Isoelectric Point: 4.3654

>T80700 WP_103136053.1 NZ_CP023278:c1026263-1025922 [Nostoc sp. CENA543]
MKIWIDAQLPPTLARWLSETFDVEAAALRELGLRDAKDVEIFNEARAVNAVILTKDSDFVDLACRLGTPPQILWLTCGNV
TNRNLQRILMIAFPDALEQLRQGEAIVEISSVS

Download         Length: 342 bp

>T80700 NZ_CP023278:c1026263-1025922 [Nostoc sp. CENA543]
ATGAAAATTTGGATTGATGCTCAATTACCTCCTACATTAGCGCGTTGGCTTAGTGAGACGTTCGATGTAGAGGCTGCTGC
ACTGCGAGAACTTGGTTTACGAGATGCTAAAGATGTTGAGATTTTTAATGAAGCACGAGCCGTTAATGCTGTTATTTTGA
CCAAAGATAGTGACTTTGTTGATTTGGCTTGTCGGTTAGGAACACCACCGCAAATTCTCTGGCTGACTTGTGGTAACGTA
ACGAATCGCAATTTGCAGCGAATACTAATGATCGCTTTTCCTGATGCACTAGAACAACTACGACAAGGAGAAGCAATCGT
AGAAATTAGCAGTGTTTCATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8608.94 Da        Isoelectric Point: 4.5203

>AT80700 WP_103140586.1 NZ_CP023278:c1026493-1026260 [Nostoc sp. CENA543]
MNSKVELLTRITQTPGQCGGRPCIRGMRIRVSDILEMLGENVSVSEILEDFPDLEAEDIQACLLFAARRTDFPRLTA

Download         Length: 234 bp

>AT80700 NZ_CP023278:c1026493-1026260 [Nostoc sp. CENA543]
ATGAACTCAAAAGTTGAATTATTAACACGTATTACCCAAACTCCTGGTCAATGTGGAGGTCGTCCTTGTATTCGCGGTAT
GAGAATCCGCGTCAGCGATATTTTAGAAATGTTGGGGGAGAATGTTAGCGTTTCTGAGATTCTAGAAGATTTTCCCGACC
TCGAAGCAGAAGATATTCAAGCTTGTTTGTTGTTTGCTGCACGCCGAACTGATTTTCCCCGACTGACAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References