Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 235626..236266 Replicon chromosome
Accession NZ_CP023276
Organism Polynucleobacter difficilis strain AM-8B5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag AOC34_RS01250 Protein ID WP_108468404.1
Coordinates 235626..236027 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag AOC34_RS01255 Protein ID WP_199908306.1
Coordinates 236027..236266 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOC34_RS01225 231569..233089 - 1521 WP_108468399.1 DNA photolyase family protein -
AOC34_RS01230 233129..233425 - 297 WP_108468400.1 hypothetical protein -
AOC34_RS01235 233581..234402 + 822 WP_108468401.1 YdcF family protein -
AOC34_RS01240 234409..235125 + 717 WP_108468402.1 YqgE/AlgH family protein -
AOC34_RS01245 235180..235617 + 438 WP_108468403.1 Holliday junction resolvase RuvX -
AOC34_RS01250 235626..236027 - 402 WP_108468404.1 type II toxin-antitoxin system VapC family toxin Toxin
AOC34_RS01255 236027..236266 - 240 WP_199908306.1 antitoxin Antitoxin
AOC34_RS01260 236510..237034 + 525 WP_108468405.1 bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase PyrR -
AOC34_RS01265 237055..238008 + 954 WP_108469979.1 aspartate carbamoyltransferase catalytic subunit -
AOC34_RS01270 238086..239501 + 1416 WP_108469980.1 hypothetical protein -
AOC34_RS01275 239555..240493 + 939 WP_108468406.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14975.29 Da        Isoelectric Point: 8.4535

>T80695 WP_108468404.1 NZ_CP023276:c236027-235626 [Polynucleobacter difficilis]
MLKYLLDTNIVIYVLKRRPKEVLGIFNANASRMAISSITLSELFYGAEKSVKTDQNLEAIEEFVSHLEVLPYDAKASQHY
GRIKAALEKKGQIIGENDIHIAAHATSHGLILVTNNLREFKRVPNLALENWVS

Download         Length: 402 bp

>T80695 NZ_CP023276:c236027-235626 [Polynucleobacter difficilis]
ATGCTCAAGTATTTGCTCGATACCAACATCGTGATCTATGTCCTCAAACGCAGACCAAAAGAAGTATTGGGAATTTTTAA
TGCTAATGCCAGTCGTATGGCAATTTCGAGTATCACCTTATCTGAACTCTTTTACGGAGCAGAAAAAAGTGTGAAAACCG
ATCAGAATTTAGAGGCAATTGAAGAATTTGTCAGTCATCTTGAGGTCCTACCCTATGATGCAAAAGCATCACAACACTAC
GGCCGAATTAAAGCTGCGCTAGAGAAAAAAGGGCAGATCATTGGAGAGAATGACATTCATATTGCAGCCCATGCTACTAG
CCACGGCTTGATTCTGGTGACGAACAATTTACGTGAATTTAAACGGGTGCCTAATTTAGCCCTAGAGAATTGGGTATCGT
AG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9033.37 Da        Isoelectric Point: 9.1096

>AT80695 WP_199908306.1 NZ_CP023276:c236266-236027 [Polynucleobacter difficilis]
MTIAITTVFSNNRTQAVRLPAEARLPDEVKRVIVRIRGRERIITPIENTWDAFFLNGPLVTNDFLNERGVQTPVEREGL

Download         Length: 240 bp

>AT80695 NZ_CP023276:c236266-236027 [Polynucleobacter difficilis]
ATGACTATCGCCATCACTACGGTTTTTAGCAATAACCGCACCCAAGCGGTTCGCCTCCCCGCAGAAGCGCGCTTGCCTGA
TGAGGTCAAGCGGGTCATCGTTCGCATTCGGGGCCGGGAAAGAATCATTACCCCGATTGAAAATACCTGGGATGCCTTTT
TCTTAAATGGTCCTTTAGTCACCAATGACTTTTTGAATGAGCGCGGCGTTCAAACGCCGGTTGAGCGCGAAGGTCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References