80694

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 5018356..5019398 Replicon chromosome
Accession NZ_CP023272
Organism Pseudomonas lurida strain MYb11

Toxin (Protein)


Gene name PP_4152 Uniprot ID A0A855QJK0
Locus tag CLM75_RS22925 Protein ID WP_034109273.1
Coordinates 5018356..5018931 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A855QJR2
Locus tag CLM75_RS22930 Protein ID WP_034109274.1
Coordinates 5018928..5019398 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM75_RS22890 5013846..5014145 + 300 WP_034109382.1 antibiotic biosynthesis monooxygenase -
CLM75_RS22895 5014765..5015145 + 381 WP_105162833.1 cupin domain-containing protein -
CLM75_RS22900 5015306..5015590 - 285 WP_069078203.1 hypothetical protein -
CLM75_RS22905 5015621..5016517 - 897 WP_034109269.1 hypothetical protein -
CLM75_RS22910 5016736..5017065 + 330 WP_069078201.1 hypothetical protein -
CLM75_RS22915 5017072..5017707 - 636 WP_034109271.1 LysE family translocator -
CLM75_RS22920 5017865..5018236 + 372 WP_098467339.1 PH domain-containing protein -
CLM75_RS22925 5018356..5018931 - 576 WP_034109273.1 PIN domain-containing protein Toxin
CLM75_RS22930 5018928..5019398 - 471 WP_034109274.1 helix-turn-helix domain-containing protein Antitoxin
CLM75_RS22935 5019591..5020754 + 1164 WP_105162834.1 S-type pyocin domain-containing protein -
CLM75_RS22940 5020769..5021056 + 288 WP_105162835.1 cloacin -
CLM75_RS22945 5021073..5021561 + 489 WP_105163163.1 hypothetical protein -
CLM75_RS22950 5021572..5022144 - 573 WP_034109277.1 hypothetical protein -
CLM75_RS22955 5022529..5023881 - 1353 WP_034109278.1 sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4994057..5021561 27504


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21538.85 Da        Isoelectric Point: 5.0339

>T80694 WP_034109273.1 NZ_CP023272:c5018931-5018356 [Pseudomonas lurida]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTSQIHEEWKRNVLKNRPDLTAEHVNCTSALMDKAIPDALVTGY
EDLCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPTQILSAYDIEPMHPDDFISDLWDLDQAAVLGAAQKQRRALKR
PPMEAGSYLEMLMRQGLAQTSKLLGPYEVML

Download         Length: 576 bp

>T80694 NZ_CP023272:c5018931-5018356 [Pseudomonas lurida]
ATGAGGTGTTCGCCTTTTACCGCTGTATATGATGCTTGTGTTCTCTACCCGGCGGCGCTTAGGGATTTGCTGATGTGGCT
TGGCCTGTCAGGGCTGTATCGAGCGAGATGGACTAGCCAGATTCATGAGGAGTGGAAGCGCAACGTACTCAAGAACCGAC
CCGATCTCACTGCTGAGCATGTGAATTGCACGTCAGCGCTGATGGACAAGGCTATACCTGACGCTTTGGTTACTGGATAT
GAGGATCTGTGTTCGAGCTTGGATCTGCCCGATCCGGATGATCGTCACGTACTGGCGGCCGCAATTCGGAGTAAAGCTGA
GGTTATTGTGACCTTCAATTTGAAAGACTTCCCGACGCAGATCCTGTCTGCTTATGACATTGAGCCGATGCATCCGGATG
ACTTTATTTCGGATCTATGGGATCTGGATCAGGCGGCGGTGCTGGGGGCTGCGCAAAAGCAGAGGCGGGCGTTGAAGCGG
CCTCCGATGGAGGCGGGAAGTTATCTTGAGATGTTGATGCGACAAGGGCTGGCACAGACAAGTAAGCTGCTTGGACCTTA
TGAGGTCATGCTATAA

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17437.06 Da        Isoelectric Point: 5.6324

>AT80694 WP_034109274.1 NZ_CP023272:c5019398-5018928 [Pseudomonas lurida]
MITNHLPKTILPLEKEVEAAVQGQRELASLLSTKFETQRIDIFDKEDKPHTLVLPTSALRLLVDILGELAIGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQRRDEESQEAMEALANQAQELGMGYDG

Download         Length: 471 bp

>AT80694 NZ_CP023272:c5019398-5018928 [Pseudomonas lurida]
ATGATCACCAATCACCTTCCCAAAACGATCCTTCCGCTGGAAAAGGAAGTCGAAGCCGCCGTACAAGGCCAGCGCGAATT
GGCGTCCTTGCTATCGACCAAATTTGAAACCCAGCGCATCGACATCTTTGACAAAGAAGACAAACCCCACACCCTCGTAC
TCCCAACCTCAGCACTGCGCCTGTTGGTGGATATCCTGGGCGAGTTGGCTATCGGCAATGCCGTCAAGGTAGTCCCGGTG
CATGCCGAACTCACCTCGCAGGAGGCCGCTGACCTGCTTAACGTTTCACGGCCACACCTGGTCAAGATGCTGGAGGAAGG
CGCTATTCCCTTTACAAAAACCGGTCGGCATCGGCGAATCCGGTTTTCGGATTTGATGGCGTTCAAGCAGCGGCGAGATG
AGGAAAGCCAGGAAGCAATGGAAGCGCTGGCGAATCAGGCCCAGGAGCTGGGAATGGGGTATGACGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855QJK0

Antitoxin

Source ID Structure
AlphaFold DB A0A855QJR2

References