Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5808937..5810555 Replicon chromosome
Accession NZ_CP023270
Organism Achromobacter spanius strain MYb73

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag CLM73_RS26305 Protein ID WP_105240940.1
Coordinates 5808937..5810292 (-) Length 452 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag CLM73_RS26310 Protein ID WP_105240941.1
Coordinates 5810295..5810555 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM73_RS26290 5804709..5807111 - 2403 WP_158685944.1 TonB-dependent siderophore receptor -
CLM73_RS26295 5807346..5808332 - 987 WP_105240938.1 FecR domain-containing protein -
CLM73_RS26300 5808345..5808848 - 504 WP_105240939.1 sigma-70 family RNA polymerase sigma factor -
CLM73_RS26305 5808937..5810292 - 1356 WP_105240940.1 type II toxin-antitoxin system HipA family toxin Toxin
CLM73_RS26310 5810295..5810555 - 261 WP_105240941.1 helix-turn-helix domain-containing protein Antitoxin
CLM73_RS26315 5810791..5812659 - 1869 WP_105240942.1 dihydroxy-acid dehydratase -
CLM73_RS26320 5812799..5813608 - 810 WP_105240943.1 helix-turn-helix transcriptional regulator -
CLM73_RS26325 5813605..5814504 - 900 WP_105240944.1 LysR family transcriptional regulator -
CLM73_RS26330 5814611..5815156 + 546 WP_105240945.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(10-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-67)


Sequences

Toxin        


Download         Length: 452 a.a.        Molecular weight: 50164.20 Da        Isoelectric Point: 7.3626

>T80693 WP_105240940.1 NZ_CP023270:c5810292-5808937 [Achromobacter spanius]
MGRRSHHRALDLWMNGDFVGVWSVQPQIGETLQYDEAWVASGRGRPLSLSLPFTPGNPPHRGQTVRSYFENLLPDSQNIR
ERVARRFQAGSTDAFSLLAEVGRDCVGAVQVMPRDVAPDPVTQVDAIALSDAQVAQALRGTLTPGPLSGHSADDDDGFRI
SIAGAQEKTAMLWLDGRWCRPHGATPTTHIFKMPLGLVGNLKFDMSHSVENEWLCSEILHAYGLPVARTQPLMFEDMKVL
AVERFDRMWWRNDDGKRWLIRLPQEDMCQATGTPPHLKYESDGGPGVRSIMKLLATSREPDRDRRTFFQSQVLFWMLRAT
DGHAKNFSIFLRPGGAYELTPLYDVLSAYPVIGTGANQLSPFKARMAMAVRTKNTHWLMRDILRRHWLAVGAEHGVVAPD
GRGVEAVVDDLVSRTPQVVRAVRDVLPPAFPEHVADTILQGLQAAADRLAG

Download         Length: 1356 bp

>T80693 NZ_CP023270:c5810292-5808937 [Achromobacter spanius]
ATGGGCCGACGTTCACACCACCGCGCTCTGGATCTCTGGATGAACGGGGACTTCGTGGGCGTCTGGAGCGTCCAGCCCCA
GATTGGCGAGACGCTCCAATACGACGAGGCATGGGTTGCCTCCGGCCGGGGGCGGCCACTCTCGCTTTCGCTTCCCTTCA
CGCCGGGCAACCCGCCGCATCGCGGGCAGACCGTGCGCAGCTATTTCGAGAACCTGCTGCCCGACAGCCAGAACATTCGC
GAACGAGTCGCGCGGCGGTTCCAGGCGGGTTCCACTGACGCGTTCTCGTTGTTGGCCGAAGTTGGCCGCGATTGTGTGGG
CGCTGTGCAGGTCATGCCCCGCGACGTCGCGCCTGACCCCGTGACGCAGGTCGACGCCATTGCGCTCAGCGATGCGCAAG
TGGCCCAGGCGCTGCGCGGCACCCTGACGCCCGGACCCCTGAGCGGCCACAGTGCAGATGACGATGACGGGTTCCGCATC
TCGATCGCCGGGGCGCAGGAAAAGACGGCCATGCTGTGGCTCGATGGTCGCTGGTGCAGGCCTCACGGCGCCACGCCGAC
CACGCATATCTTCAAGATGCCGCTCGGCCTCGTCGGCAACTTGAAGTTCGACATGAGCCACTCGGTGGAGAACGAGTGGC
TGTGCTCCGAGATCCTCCATGCGTACGGGCTGCCGGTGGCTCGCACCCAGCCGTTGATGTTCGAGGACATGAAGGTGCTG
GCGGTCGAGCGGTTCGACCGCATGTGGTGGCGCAACGATGACGGCAAGCGCTGGCTGATCCGCCTGCCGCAGGAAGACAT
GTGCCAAGCGACGGGAACGCCGCCGCATCTGAAGTACGAATCCGACGGCGGCCCGGGCGTGCGCAGCATCATGAAGCTGC
TGGCCACCTCGCGCGAGCCCGATCGCGACCGGCGCACGTTTTTCCAATCGCAGGTCCTGTTCTGGATGTTGCGCGCCACC
GATGGCCACGCAAAGAACTTCAGCATTTTTCTGCGGCCCGGCGGCGCGTACGAGCTCACGCCGCTGTACGACGTACTGTC
TGCCTATCCCGTCATCGGTACCGGCGCCAACCAGCTGTCGCCGTTCAAGGCACGCATGGCCATGGCTGTGCGCACGAAGA
ACACCCATTGGCTCATGCGCGACATCCTGCGGCGGCATTGGCTCGCCGTCGGTGCGGAACACGGTGTCGTGGCGCCGGAC
GGCCGGGGCGTGGAGGCGGTGGTCGACGACCTGGTTTCGCGTACGCCGCAAGTGGTGCGCGCGGTGCGAGACGTATTGCC
GCCCGCGTTTCCCGAGCACGTGGCCGATACCATCCTCCAGGGCCTGCAAGCCGCGGCCGACAGACTGGCGGGATAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9300.71 Da        Isoelectric Point: 11.1107

>AT80693 WP_105240941.1 NZ_CP023270:c5810555-5810295 [Achromobacter spanius]
MSDFTVRTADQLPALLRAFRKQAGMTQAAAALRLGVTQQTLSAFERNAGKLGADRLLEILGILGVEVVLRQREKSSASKT
SATPDW

Download         Length: 261 bp

>AT80693 NZ_CP023270:c5810555-5810295 [Achromobacter spanius]
ATGTCCGACTTCACCGTCCGCACGGCGGACCAGCTCCCCGCCTTGCTCCGGGCCTTCCGCAAACAGGCTGGCATGACCCA
GGCCGCGGCTGCACTGCGTCTGGGCGTCACGCAGCAGACGCTTTCAGCGTTTGAGCGCAACGCCGGCAAGCTTGGCGCTG
ACAGGTTGCTGGAGATTCTCGGCATCCTGGGCGTGGAAGTCGTGTTGCGCCAACGGGAAAAATCCTCCGCGTCCAAAACA
TCGGCCACACCGGATTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References