Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2367746..2368422 Replicon chromosome
Accession NZ_CP023270
Organism Achromobacter spanius strain MYb73

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CLM73_RS10565 Protein ID WP_105238389.1
Coordinates 2367746..2368168 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag CLM73_RS10570 Protein ID WP_105238390.1
Coordinates 2368165..2368422 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLM73_RS10550 2363339..2364010 + 672 WP_199778323.1 MarC family NAAT transporter -
CLM73_RS28890 2364282..2364512 + 231 WP_156395263.1 hypothetical protein -
CLM73_RS10555 2364562..2365848 - 1287 WP_199778279.1 LLM class flavin-dependent oxidoreductase -
CLM73_RS10560 2366228..2367679 + 1452 WP_105238388.1 sodium:solute symporter family protein -
CLM73_RS10565 2367746..2368168 - 423 WP_105238389.1 type II toxin-antitoxin system VapC family toxin Toxin
CLM73_RS10570 2368165..2368422 - 258 WP_105238390.1 Arc family DNA-binding protein Antitoxin
CLM73_RS10575 2368831..2369529 + 699 WP_105238391.1 metallophosphoesterase -
CLM73_RS10585 2369819..2370601 - 783 WP_105238392.1 exodeoxyribonuclease III -
CLM73_RS10590 2370847..2371068 - 222 WP_105238393.1 hypothetical protein -
CLM73_RS10595 2371156..2371938 - 783 WP_105238394.1 3-oxoacyl-ACP reductase -
CLM73_RS10600 2371957..2372760 - 804 WP_105238395.1 FadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-129)

Antitoxin

Arc-like DNA binding domain

(12-46)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15172.64 Da        Isoelectric Point: 7.1658

>T80692 WP_105238389.1 NZ_CP023270:c2368168-2367746 [Achromobacter spanius]
MIVLDTNVISEAWKPQPSAQVMQWIDAQNAETLFISAITIAELRLGLAVMPSSKRHDHFCRLLEKELLPAFFGRILPFDL
EASGAYSLLMAKARKAGKAISAADGYIAATAATRGMIVASRDTAPFKAADVAVINPWNDV

Download         Length: 423 bp

>T80692 NZ_CP023270:c2368168-2367746 [Achromobacter spanius]
ATGATCGTTCTTGATACCAACGTCATTTCGGAAGCCTGGAAGCCACAACCCTCCGCGCAAGTGATGCAGTGGATAGATGC
CCAGAACGCCGAGACACTTTTCATATCGGCCATCACCATCGCGGAACTGCGACTTGGGTTGGCGGTCATGCCGTCAAGCA
AGCGACACGATCACTTTTGCCGACTCTTGGAAAAAGAATTGCTGCCGGCATTCTTCGGGCGCATCCTGCCGTTCGACCTG
GAGGCTTCGGGCGCATATTCCCTTTTAATGGCAAAGGCGCGCAAAGCGGGTAAAGCCATCAGCGCAGCCGACGGCTACAT
CGCGGCAACGGCCGCAACGCGCGGCATGATTGTCGCCAGCCGCGATACGGCCCCCTTCAAGGCCGCTGACGTCGCTGTCA
TCAATCCTTGGAACGACGTTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9317.62 Da        Isoelectric Point: 10.5807

>AT80692 WP_105238390.1 NZ_CP023270:c2368422-2368165 [Achromobacter spanius]
MASITVRNISDEVHRALRARAAKHGRSTEAEVRAILEQAARPEGRLKIGSLLASFAHKAGPLTETEVESINGVRDKRPAK
PMDFE

Download         Length: 258 bp

>AT80692 NZ_CP023270:c2368422-2368165 [Achromobacter spanius]
ATGGCCTCGATCACCGTCCGCAATATTTCCGACGAAGTGCACCGCGCGCTGCGTGCGCGCGCGGCCAAGCATGGCCGAAG
CACCGAAGCAGAAGTTCGCGCCATTCTCGAACAAGCAGCACGCCCCGAGGGCCGCCTCAAGATTGGCTCTCTATTAGCGT
CCTTCGCCCACAAAGCCGGTCCCCTGACCGAAACAGAGGTTGAATCCATCAACGGGGTCCGCGACAAGCGACCTGCCAAA
CCGATGGATTTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References